Optimal management of brain metastases in oncogenic-driven non-small cell lung cancer (NSCLC)

Lung cancer is the leading cause of cancer-related mortality in both men and women. Non-small cell lung cancer (NSCLC) accounts for 85-90% of all lung cancer incidence [6] and also represents the most common cause of cerebral metastasis either at diagnosis or at relapse/progression [7]. Approximately 10-20% of NSCLC patients will have brain metastasis at initial presentation [8,9]. Another 25-50% will develop brain metastases during the course of their disease [10]. Among NSCLC histological subtypes, non-squamous carcinomas carry a greater risk for extra-thoracic metastasis compared to squamous cell histologies [11].

Source: Lung Cancer - December 10, 2018 Category: Cancer & Oncology Authors: Nicolaus Andratschke, Johannes Kraft, Carsten Nieder, Rebecca Tay, Raffaele Califano, Riccardo Soffietti, Matthias Guckenberger Tags: Review Source Type: research