Prediction of ESRD in IgA Nephropathy Patients from an Asian Cohort: A Random Forest Model

Conclusion: In addition to the predictors in the CDSS, Oxford-MEST scores, C3 staining and eGFR conveyed additional information for ESRD prediction in Chinese IgAN patients using a RF model.Kidney Blood Press Res 2018;43:1852 –1864
Source: Kidney and Blood Pressure Research - Category: Urology & Nephrology Source Type: research

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Publication date: Available online 20 June 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Antonino Tuttolomondo, Domenico Di Raimondo, Alessandra Casuccio, Mariachiara Velardo, Giovanni Salamone, Valentina Arnao, Rosaria Pecoraro, Vittoriano Della Corte, Vincenzo Restivo, Francesca Corpora, Carlo Maida, Irene Simonetta, Anna Cirrincione, Valerio Vassallo, Antonio PintoAbstractIntroductionAlthough some authors evaluated the relationship between adherence to Mediterranean Diet (MeDi) and both ischemic and hemorrhagic stroke, hemorrhagic stroke was not yet examined alone.Aimswe conducted a retrospecti...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
ConclusionThe activity and safety of first-line FOLFIRI/aflibercept merit further evaluation in randomized studies.Clinicaltrials.gov registration numberNCT02624726.
Source: Targeted Oncology - Category: Cancer & Oncology Source Type: research
Background: Thyroid cancer has become the most common cancer in Korea. Generally, thyroid cancer patients have a good prognosis; however, 15%–20% of patients experience recurrence or distant metastasis or are refractory to standard treatment. We assessed the safety of sorafenib and lenvatinib in patients with advanced or metastatic radioactive iodine-refractory differentiated thyroid cancers (DTC) consecutively treated at a tertiary center in South Korea. Methods: We retrospectively reviewed the charts of all consecutive patients with DTC treated during ≥6 months with lenvatinib (February 2016–April 2018) a...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusions: Treatment with apatinib provides an additional option for the treatment of patients with GISTs refractory to imatinib and sunitinib.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Abstract Based on previous studies suggesting a role of renal nerves in renal inflammation, the present studies were performed to test the hypothesis that renal nerves mediate renal damage in Dahl salt-sensitive (SS) hypertension by increasing renal leukocyte infiltration. Experiments were performed in Dahl SS rats using both bilateral renal denervation (RDN) or bilateral sham operation (n=10-11 per group); and using unilateral RDN and contralateral sham (n=10). Following denervation, rats were switched from a low salt 0.4% NaCl (LS) to a high salt 4% NaCl (HS) diet and maintained on HS for twenty-one days. Bilate...
Source: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology - Category: Physiology Authors: Tags: Am J Physiol Regul Integr Comp Physiol Source Type: research
(Abstracted from Lancet 2019;393:330–339) Hypertension complicates 5% of all pregnancies and 11% of first pregnancies, and half of these cases are associated with preeclampsia (gestational hypertension plus proteinuria). Hypertensive disorders of pregnancy are the direct cause of death of approximately 30,000 women annually, or approximately 14% of maternal deaths, most of which occur in low-income countries.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: OBSTETRICS: PRECONCEPTION AND PRENATAL CARE Source Type: research
Diabetic kidney disease is a serious microvascular complication of diabetes mellitus and the leading cause of end-stage renal disease in western countries. New therapeutic agents are needed to delay its onset and progression. Recent literature suggests that sodium-glucose cotransporter 2 (SGLT-2) inhibitors may have renoprotective effects. Our aim was to systematically review the effect of SGLT-2 inhibitors on albuminuria and proteinuria in patients with diabetes mellitus. Studies were identified by search in major electronic databases, clinical trial registers, and sources of gray literature. We included randomized contro...
Source: Journal of Hypertension - Category: Cardiology Tags: REVIEWS Source Type: research
Abstract Chronic kidney disease represents a heterogeneous group of disorders characterized by alterations in the structure and function of the kidney. Chronic kidney disease significantly increases the risk of adverse maternal and perinatal outcomes, and these risks increase with the severity of the underlying renal dysfunction, degree of proteinuria, as well as the frequent coexistence of hypertension. Further, renal anatomic changes result in dilatation of the collecting system, and physiologic adaptations include alterations in the balance of vasodilatory and vasoconstrictive hormones, resulting in decreased s...
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Authors: Zhu Y, Feng B, Mei L, Sun R, Guo C, Zhu J Abstract PURPOSE: To explore the therapeutic efficacy and clinical safety of transcatheter arterial chemoembolization (TACE) combined with Apatinib in patients with advanced hepatocellular carcinoma (HCC). METHODS: 88 patients with advanced HCC admitted to our hospital from March 2015 to March 2016 were randomly assigned into group A (TACE) or B (TACE combined with Apatinib). Therapeutic efficacy and adverse events were recorded by follow-up data every three months after treatment. Disease control rate (DCR) and objective response rate (ORR) in both groups were...
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
CONCLUSION: These results suggest that serum soluble ST2 levels on admission could be a useful biomarker of subsequent renal scarring in pediatric patients with upper urinary tract infection. PMID: 31153005 [PubMed - as supplied by publisher]
Source: Cytokine - Category: Molecular Biology Authors: Tags: Cytokine Source Type: research
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