[PERSPECTIVES] Regulatory T Cells: From Discovery to Autoimmunity

Multiple sclerosis (MS) is a genetically mediated autoimmune disease of the central nervous system. Allelic variants lead to lower thresholds of T-cell activation resulting in activation of autoreactive T cells. Environmental factors, including, among others, diet, vitamin D, and smoking, in combination with genetic predispositions, play a substantial role in disease development and activation of autoreactive T cells. FoxP3+ regulatory T cells (Tregs) have emerged as central in the control of autoreactive T cells. A consistent finding in patients with MS is defects in Treg cell function with reduced suppression of effector T cells and production of proinflammatory cytokines. Emerging data suggests that functional Tregs become effector-like T cells with loss of function associated with T-bet expression and interferon (IFN-) secretion.

Source: Cold Spring Harbor perspectives in medicine - December 3, 2018 Category: Research Authors: Kitz, A., Singer, E., Hafler, D. Tags: Multiple Sclerosis PERSPECTIVES Source Type: research