Coronary Artery Disease: the magnificent fifty?

Coronary artery disease (CAD) remains the leading cause of death in the US. Altered cholesterol metabolism and pro-inflammatory mechanisms have been associated with the development of atherosclerotic plaques [1]. Only recently, large scale genetic approaches using genome wide association studies (GWAS) have identified novel genetic markers and unsuspected pathways have been exposed along with their potential application to CAD. In the review article in this issue of the Journal, titled “A genetic basis for coronary artery disease”, Dr.
Source: Trends in Cardiovascular Medicine - Category: Cardiology Authors: Source Type: research