The fat mass and obesity related gene polymorphism influences the risk of rejection in heart transplant patients

AbstractHeart transplantation is a relatively common treatment for end ‐stage heart failure. The major complication of heart transplantation is organ rejection. Epigenetic could play a role in the pathogenesis of organ rejection, and theFTO gene is a mediator of DNA methylation. We analyzed a taggingFTO SNP rs17817449 in both donor and recipient DNA obtained through 370 heart transplantations. RecipientFTO genotypes were not associated with either type of rejection or with the general increase in the risk of rejection. When compared with patients without a history of rejection, carriers of transplanted hearts with theFTO TT genotype exhibited a significantly increased risk (P = 0.02) of suffering from both types of rejection in comparison to carriers of hearts with at least one G allele (OR; 95% CI = 2.56; 1.15‐5.69). Our results suggest that the donor, but not the recipient,FTO genotype could be a significant predictor of acute rejection in heart transplant patients.
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: BRIEF COMMUNICATION Source Type: research