Various Gvhd Prophylaxis Regimens Influence Differently T-Memory Cell Subsets Recovery after Allogeneic Stem Cell Transplantation in Leukemia Patients

Conclusion. New immunosuppressive approaches are now available for GVHD prophylaxis for patients who undergoes allo-HSCT from mismatched or haplo- donors that provides comparable results with classical immunosuppression in case of matched allo-HSCT. However Tnv+Tscm is the progenitor subset for all memory T-cells and its prompt recovery after allo-HSCT seems to be crucial for graft-versus-leukemia effect. Here we show the lowest number of Tnv+Tscm after alternative GVHD prophylaxis regimens that can be explained by more sever immunoablation. Through this it may lead to delayed reconstitution of adaptive immunity after alternative immunosuppression in patients after allo-HSCT.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Drokov, M., Popova, N., Parovichnikova, E., Kuzmina, L., Davydova, J., Kapranov, N., Mikhaltsova, E., Koroleva, O., Vasilyeva, V., Dubnyak, D., Konova, Z., Sidorova, A., Usikova, E., Dmitrova, A., Galtseva, I. V., Maschan, M., Savchenko, V. G. Tags: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution Source Type: research