PIG-a Gene Expression Deficiency Association with Reduced DNA Damage Checkpoint Response and Activation

Conclusion:The above-mentioned results showed that there were decreased expressions of both DNA damage response checkpoint genes and repair genes in both the PIG-A CRISPR knockout leukemia cell lines as well as in the PNH patients. PIG-A mutation is globally associated with reduced DNA damage response capability and increased cellular stability. Our finding explains, at least partially, why PIG-A gene mutation status could be seen as a biomarker of mutagenesis and how PNH cells dominantly expend via clonal escape.DisclosuresNo relevant conflicts of interest to declare.

Source: Blood - November 21, 2018 Category: Hematology Authors: Pu, J. J., Lu, S., Nemesure, M., Teye, E. K., Schleicher, E., Moldovan, G.-L., Brodsky, R. A., Chen, F. Tags: 508. Bone Marrow Failure: Poster III Source Type: research