Autoreactivity in patients with respiratory sarcoidosis

Sarcoidosis (SC) is a granulomatous disease with unknown origin and autoimmune features. The autoantigen that triggers the pathological process is unknown.Aim: To study autoreactivity in patients with SC by determining the level of autoantibodies.Methods: In Institute of Phthisiopulmonology in 2017, patients with histologically verified pulmonary SC stage 2 (n=21, 13 men and 8 women, mean age 34.2 ± 7.3 years) were examined. The level of autoantibodies of the standard panel (15 indicators) was determined by ELISA. Statistical analysis was done by Statistica 7.0 with the methods of descriptive statistics (N, % or Mean ±SD).Results: An increased level of autoantibodies to modified citrullinated vimentin (anti-MCV) - 44.8 (±26) U/ml was determined in 7(33%) patients. In 2 (9.5%) autoantibodies to C1q complement factor (a_C1q) – 10.2 (± 0.27) U/ml, in 2 (9.5%) to beta-2-glycoprotein (b2GP) – 25.08 (±2.7) RU/ml were determined. An elevated level of anti-thyroglobulin autoantibodies (a-TG) – 398.2 U/ml, antinuclear antibodies (ANA) – 1:1280, cardiolipin antibodies (ACLA) – 12.39 u/ml was detected once each (4.8%) (Figure). Consclusion: Detection of elevated levels of autoantibodies, primarily to peptides derived from vimentin may indicate a high probability of the involvement of autoimmune factors in the development of SC and requires further study of antivimentin immunoreactivity in the SC.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sarcoidosis and other granulomatous ILD/DPLD Source Type: research