Lung dendritic cells correlate to small airway abnormality & lung CD4+ T cells: SPIROMICS bronchoscopy study

Conclusions: These data suggest that lung cDC may limit SAA via beneficial T cell polarization occurring only in ex-smokers. Confirming differences based on smoking status in DC-CD4+ T cell interactions in the lungs will require functional assessments, which are planned in SPIROMICS II.

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Kady, M., Christenson, S., Stolberg, V., Bates, M., Labaki, W., Alexis, N., Barjaktarevic, I., Barr, G., Bleecker, E., Boucher, R., Bowler, R., Cooper, C., Couper, D., Doerschuk, C., Han, M., Hansel, N., Hastie, A., Hoffman, E., Kaner, R., Martinez, F., M Tags: Airway Cell Biology and Immunopathology Source Type: research