Cytokines/chemokines gene expression in the lungs of fibrous-cavernous TB patients.

Conclusions: In the present study, we demonstrated that cells in caverna wall expressed lower levels of neutrophil chemoattractants CXCL1/CXCL2 as compared with the cells in surrounding lung tissue. Thus M. tuberculosis inside the cavity was protected from neutrophilic influx. Our data emphasize the role of neutrophil-derived inflammation in post primary lung TB.This work was supported by the Russian Scientific Foundation (grant 16-15-10242).

http://erj.ersjournals.com/cgi/content/short/52/suppl_62/PA4731?rss=1

Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Shepelkova, G., Evstifeev, V., Yeremeev, V., Ergeshova, A., Bagirov, M. Tags: Tuberculosis Source Type: research