Pharmacological treatment of stable Chronic Obstructive Pulmonary Disease: Where do we stand?

Conclusion: Despite efforts made, COPD is not fully treated as recommended by GOLD in 2017, most patients receive ICS without considering asthma associated diagnosis or exacerbation history
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Airway pharmacology and treatment Source Type: research

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Conclusion: Influenza with CLD is associated with longer length of stay in under 50’s compared to non-CLD. Readmission and mortality were higher in CLD patients.Table 1.AgeNo of patientsPts with CLDsMean Hospital stay (Days)Pts without CLDsMean Hospital Stay(Days)18-30417(17%)11.234(83%)1.231-505818(31%)5.240(69%)2.651-6511143(39%)8.168(61%)7.566-7513956(40%)9.683(60%)11.576-8516352(32%)14111(68%)15.586-9915642(27%)19.5114(73%)20.2
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical Problems Source Type: research
Rationale: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and COPD. IFN-β is a key component of the innate immune response to viral infection. However, in the recent INEXAS clinical trial, on-demand IFN-β treatment of asthmatics failed to prevent severe exacerbations.Objectives: The dynamics of exogenous IFN-β activity were investigated to inform on future clinical indications for this potential anti-viral therapy.Methods: Monocyte-derived macrophages (MDMs), alveolar macrophages and primary bronchial epithelial cells (PBECs) were isolated from healthy control...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Introduction: Eosinophils (eos) count are related to inhaled corticosteroids response in exacerbator phenotype in COPD. The main goal of this work was to test the hypothesis of the relationship between peripheral blood eosinophil count and bronchiectasis exacerbations.Methods: Retrospective cohort study. Patients followed in a specialized bronchiectasis consultation in Centro Hospitalar de Leiria (Portugal) were consecutively included from 01/2017 to 01/2019. Patients on chronic oral steroids were excluded. Peripheral blood eosinophils count at beginning of the study was compared. Patients were divided into 2 groups: G1 (&...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusions: In this year follow up, PV had already a beneficial impact in decreasing the severity of RI in CRP.Reference:1. Martins RN, Vaz LR. Influenza and Pneumococcal Vaccination in Chronic Respiratory Patients-Are We in the Right Path?. Arch bronconeumol. 2019 Jan
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Conclusions: Despite the availability and broad use of pertussis containing vaccines in the setting of pregnancy and infants, use of these vaccines in Australian adults remains limited. These findings highlight a significant opportunity to improve awareness and uptake of pertussis containing vaccines in individuals with chronic respiratory disease.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
Introduction: Patients with chronic obstructive pulmonary disease (COPD) have higher risk of hospitalization for cardiovascular events (CVE). An association between influenza infection and myocardial infarction (MI) is established. Our objective is to evaluate the COPD as an additional risk factor for CVE and respiratory events (RE) in patients with respiratory viral infection.Methods: We performed a retrospective cross-sectional analysis of 139 patients, with positive PCR for respiratory viruses in January of 2018. Cardiovascular risk factors (CVRF) (hypertension, diabetes, dyslipidemia and smoking) and medical history we...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring airway disease Source Type: research
Conclusions: In this cohort of elderly patients, those with cardiac failure and COPD or asthma were more prone to being submitted to NIV or IMV. RSV infection was associated with higher mortality independently of significant co-morbidities.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Respiratory infections Source Type: research
What can we expect from the flu season this year? Unfortunately, many experts are predicting an active, and possibly severe, flu season. This projection is based on data from Australia, where the flu season is just wrapping up. Australia was hit early and hard by flu this year: over 300,000 patients had laboratory-confirmed influenza, a record number of cases. Flu outbreaks in the Southern Hemisphere happen during our summers, and they often give us a clue as to what we should expect when the flu lands on our shores in the fall. Who should get the flu vaccine? Basically, everybody over the age of 6 months, except for those...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cold and Flu Health Prevention Vaccines Source Type: blogs
Publication date: Available online 15 October 2019Source: Pharmacology &TherapeuticsAuthor(s): Edward D. Chan, Michael M. Chan, Mallory M. Chan, Paul E. MarikAbstractGlucocorticoids (GC) in all its various forms and formulations are likely one of the most commonly used pharmacologic agents in medicine. Their use can be profoundly therapeutic but are also associated with a myriad of acute and chronic side effects. It is fairly well-accepted in the medical community that GC can be life-saving when used in critically ill patients with severe exacerbations of asthma and chronic obstructive pulmonary disease, HIV-associated...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
Dynamics of IFN-β Responses During Respiratory Viral Infection: Insights for Therapeutic Strategies. Am J Respir Crit Care Med. 2019 Aug 28;: Authors: Watson A, Spalluto CM, McCrae C, Cellura D, Burke H, Cunoosamy D, Freeman A, Hicks A, Hühn M, Ostridge K, Staples KJ, Vaarala O, Wilkinson T Abstract RATIONALE: Viral infections are major drivers of exacerbations and clinical burden in patients with asthma and COPD. IFN-β is a key component of the innate immune response to viral infection. To date studies of inhaled IFN-β treatment have not demonstrated a significant effect on asthma...
Source: American Journal of Respiratory and Critical Care Medicine - Category: Respiratory Medicine Authors: Tags: Am J Respir Crit Care Med Source Type: research
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