Impact of lowering pulmonary vascular resistance on right and left ventricular deformation in pulmonary arterial hypertension

ConclusionsPAH is associated with impaired biventricular deformation. Reduction in PVR is associated with improvements in both RV and LV deformation, coupled to improvements in MPAP and stroke volume index, with LV global and septal CS the strongest correlates of these changes. RV FWLS is sensitive to treatment effect, demonstrating greater improvement with imatinib compared with placebo.Trial registration: NCT00902174

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1002%2Fejhf.177

Source: European Journal of Heart Failure - November 1, 2014 Category: Cardiology Authors: Gabriela Querejeta Roca, Patricia Campbell, Brian Claggett, Ali Vazir, Debbie Quinn, Scott D. Solomon, Amil M. Shah Tags: Original Article Source Type: research