Urine biomarkers of chronic kidney damage and renal functional decline in childhood-onset systemic lupus erythematosus

ConclusionIn combination, urinary levels of adiponectin and osteopontin predict chronic LN damage with similar accuracy as the GFR. Ongoing LN activity as reflected by high levels of LN activity biomarkers heralds renal functional decline.Key messages• Levels of osteopontin and adiponectin measured at the time of kidney biopsy are good predictors of histological damage with lupus nephritis.• Only about 20% of children with substantial kidney damage from lupus nephritis will have an abnormally low urine creatinine clearance.• Continuously high levels of biomarkers reflecting lupus nephritis activity are risk factors of declining renal function.
Source: Pediatric Nephrology - Category: Urology & Nephrology Source Type: research