Varenicline for long term smoking cessation in patients with COPD

Publication date: Available online 3 November 2018Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Rafael J. Hernández Zenteno, Danitza Fernández Lara, Alejandra Ramírez Venegas, Raúl H. Sansores, Justino Regalado Pineda, Fernando Flores Trujillo, José Rogelio Pérez Padilla, Maria Gabriela Matera, Mario CazzolaAbstractBackgroundQuitting smoking is key for patients with Chronic Obstructive Pulmonary Disease (COPD). Standard recommendations for quitting smoking are implemented for COPD as well. Varenicline Tartrate (VT) is the most effective drug to help quit smoking, but few studies have analyszed its effectiveness.Aim of the study: To determine the Abstinence Rate (AR) at 12 months, in COPD and non-COPD smokers.MethodsObservational study in 31 COPD (post bronchodilator-BD FEV1/FVC
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research

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Publication date: Available online 14 November 2019Source: Journal of Pharmacological SciencesAuthor(s): Mitsuhisa Koga, Yuki Kanaoka, Mana Okamoto, Yuki Nakao, Koshun Inada, Saki Takayama, Yasufumi Kataoka, Atsushi YamauchiAbstractVarenicline is a widely used and effective drug for smoking cessation. We previously reported that varenicline aggravates atherosclerosis in apolipoprotein E knockout (ApoE KO) mice. However, it remains unknown whether varenicline affects cardiovascular events in patients with nicotine addiction. Here, we examined the effect of varenicline on atherosclerotic plaque formation in nicotine-pretreat...
Source: Journal of Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Heart failure (HF) and chronic obstructive pulmonary disease (COPD) are both common causes of breathlessness and often conspire to confound accurate diagnosis and optimal therapy. Risk factors (such as aging, smoking, and obesity) and clinical presentation (eg, cough and breathlessness on exertion) can be very similar, but the treatment and prognostic implications are very different. This review discusses the diagnostic challenges in individuals with exertional dyspnea. Also highlighted are the prevalence, clinical relevance, and therapeutic implications of a concurrent diagnosis of COPD and HF.
Source: Heart Failure Clinics - Category: Cardiology Authors: Source Type: research
In conclusion, we have demonstrated that specific pMRTPs, namely THS 2.2 and MESH 1.1, have a significantly lower MAO-inhibitory activity than 3R4F. These findings provide a basis for further investigation of the role of MAO inhibitors in cigarette addiction as well as the implications of the findings for abuse liability of pMRTPs in comparison with cigarettes.Graphical Abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research
Conclusions: A series of 10 observational studies was or are being conducted in response to the FDA's postmarketing requirement. All studies have been feasible to conduct, although a validated algorithm for measuring abuse and addiction in databases was not successful. PMID: 31721609 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
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Source: Journal of Pharmacokinetics and Pharmacodynamics - Category: Drugs & Pharmacology Source Type: research
We examined these associations among individuals who ever repo...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Oncobiome at the Forefront of a Novel Molecular Mechanism to Understand the Microbiome and Cancer. Adv Exp Med Biol. 2019;1168:147-156 Authors: Astudillo-de la Vega H, Alonso-Luna O, Ali-Pérez J, López-Camarillo C, Ruiz-Garcia E Abstract The microbiome comprises all the genetic material within a microbiota, that represents tenfold higher than that of our cells. The microbiota it includes a wide variety of microorganisms such as bacteria, viruses, protozoans, fungi, and archaea, and this ecosystem is personalized in any body space of every individual. Balanced microbial communities ca...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
Conclusions The physical stressors of either driving or servicing the race car are overlaid with particular environmental challenges associated with racing (e.g., thermal, noise, carbon monoxide exposure) that increase the physiological stress on motorsport athletes. Physical stress reflects the muscular work required for car control and control of posture during high gravitational (g) loads: factors that predispose athletes to fatigue. The physiologic effects of these stressors include cardiovascular stress as reflected by prolonged elevation of heart rate, cardiac output, and oxygen consumption in both driver and pit a...
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research
This study was, hence, aimed at performing a comparative study to compare the linear elastic and nonlinear hyperelastic mechanical properties of the healthy nonsmokers and unhealthy smokers' lung using uniaxial tensile testing under two different loading directions, i.e., the axial and transversal. To do that, the COppm (Carbon Monoxide part per million) and %COHb (blood Carboxyhemoglobin) of 18 cadaveric individuals, including 9 nonsmokers and 9 smokers were measured. The COppm and %COHb were found to be 26 ± 1.58 (Mean ± SD) and 4 ± 1.16 for the smokers and 4.79 ± 0.25 and 1.27 ...
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research
Follow me at @JohnRossMD Americans are confused about electronic cigarettes. A recent poll showed that the public was about evenly split between those who thought that electronic cigarettes, or e-cigarettes, were less harmful than conventional cigarettes, and those who believed that e-cigarettes were as bad as or worse than regular cigarettes. Unfortunately, there is no long-term safety data about e-cigarettes. What information we do have suggests that e-cigarettes have a complex mix of potential harms and benefits. E-cigarettes: Less deadly than regular cigarettes First, the good news: e-cigarettes are almost certainly le...
Source: New Harvard Health Information - Category: Consumer Health News Authors: Tags: Behavioral Health Cancer Lung disease Prevention Smoking cessation Source Type: news
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