CZ-7, a new derivative of Claulansine F, ameliorates 2VO-induced vascular dementia in rats through a Nrf2-mediated antioxidant responses.

In conclusion, CZ-7 has therapeutic potential for VD by alleviating oxidative stress injury through Nrf2-mediated antioxidant responses.
PMID: 30382185 [PubMed - as supplied by publisher]

Source: Acta Pharmacologica Sinica - October 31, 2018 Category: Drugs & Pharmacology Authors: Liu DD, Yuan X, Chu SF, Chen C, Ren Q, Luo P, Lin MY, Wang SS, Zhu TB, Ai QD, Zang YD, Zhang DM, He X, Huang ZH, Sun HS, Feng ZP, Chen NH Tags: Acta Pharmacol Sin Source Type: research