A study identifies new markers associated with protection by the RTS,S malaria vaccine

(Barcelona Institute for Global Health (ISGlobal)) Protection conferred by the RTS,S malaria vaccine depends greatly on the amount and subclass of antibodies generated upon vaccination, and on previous exposure levels to the parasite, according to a study led by ISGlobal, an institution supported by 'la Caixa' Foundation. The results, published in BMC Medicine, shed new light on the mechanisms by which RTS,S confers protection and provide the basis for developing more efficacious vaccines.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research
Engineered Plasmodium parasites form the basis of two experimental malaria vaccines that showed safety and encouraging immune responses in clinical trials.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
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Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
This study demonstrates that PbVac immunization elicits a marked biological effect, inhibiting a subsequent infection by the human Pf parasite, and establishes the clinical validation of a new paradigm in malaria vaccination.
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Immunization with attenuated Plasmodium sporozoites can induce protection against malaria infection, as shown by Plasmodium falciparum (Pf) sporozoites attenuated by radiation in multiple clinical trials. As alternative attenuation strategy with a more homogeneous population of Pf sporozoites (PfSPZ), genetically engineered Plasmodium berghei sporozoites (SPZ) lacking the genes b9 and slarp induced sterile protection against malaria in mice. Consequently, PfSPZ-GA1 Vaccine, a Pf identical double knockout (Pfb9slarp), was generated as a genetically attenuated malaria parasite vaccine and tested for safety, immunogenicity, a...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
Contributors : Gemma Moncunill ; Anja Scholzen ; Maximillian Mpina ; Augusto Nhabomba ; Aurore B Hounkpatin ; Lourdes Osaba ; Raquel Valls ; Joseph J Campo ; H èctor Sanz ; Chenjerai Jairoce ; Nana A Williams ; Erica M Pasini ; David Arteta ; Joan Maynou ; Lourdes Palacios ; Miquel Duran-Frigola ; John J Aponte ; Clemens H Kocken ; Selidji T Agnandji ; José M Mas ; Benjamin Mordmüller ; Claudia Daubenberger ; Robert Sauerwein ; Carlota DobañoSeries Type : Expression profiling by arrayOrganism : Homo sapiensIdentifying immune correlates of protection and mechanisms of immunity accelerates and strea...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Identifying immune correlates of protection and mechanisms of immunity accelerates and streamlines the development of vaccines. RTS,S/AS01E, the most clinically advanced malaria vaccine, has moderate efficacy in African children. In contrast, immunization with sporozoites under antimalarial chemoprophylaxis (CPS immunization) can provide 100% sterile protection in naìˆve adults. We used systems biology approaches to identifying correlates of vaccine-induced immunity based on transcriptomes of peripheral blood mononuclear cells from individuals immunized with RTS,S/AS01E or chemoattenuated sporozoites stimulated with paras...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
s JA, de Koning-Ward T, Barry AE, Barchet W, Cockburn IA, McFadden GI, Gras S, Lahoud MH, Bertolino P, Schittenhelm RB, Caminschi I, Heath WR, Fernandez-Ruiz D Abstract Liver-resident memory CD8+ T (TRM) cells remain in and constantly patrol the liver to elicit rapid immunity upon antigen encounter and can mediate efficient protection against liver-stage Plasmodium infection. This finding has prompted the development of immunization strategies where T cells are activated in the spleen and then trapped in the liver to form TRM cells. Here, we identify PbRPL6120-127, a H2-Kb-restricted epitope from the putative...
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research
Authors: Niyibizi JB, Kirira PG, Kimani FT, Oyatsi F, Ng'ang'a JK Abstract Malaria is a disease caused by protozoans transmitted to humans by infected female Anopheles mosquitoes. According to the WHO report of 2015, there were 214 million cases of malaria with 438,000 deaths worldwide. Ninety percent of world's malaria cases occur in Africa, where the disease is recognized as a serious impediment to economic and social development. Despite advancement in malaria research, the disease continues to be a global problem, especially in developing countries. Currently, there is no effective vaccine for malaria control. ...
Source: Journal of Tropical Medicine - Category: Tropical Medicine Tags: J Trop Med Source Type: research
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