Mutant UBQLN2 promotes toxicity by modulating intrinsic self-assembly [Neuroscience]

UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality control and integrally tied to human neurodegenerative disease. Whereas wild-type UBQLN2 accumulates in intraneuronal deposits in several common age-related neurodegenerative diseases, mutations in the gene encoding this protein result in X-linked amyotrophic lateral sclerosis/frontotemporal dementia associated with...

Source: Proceedings of the National Academy of Sciences - October 30, 2018 Category: Science Authors: Lisa M. Sharkey, Nathaniel Safren, Amit S. Pithadia, Julia E. Gerson, Mark Dulchavsky, Svetlana Fischer, Ronak Patel, Gabrielle Lantis, Naila Ashraf, John H. Kim, Alia Meliki, Eiko N. Minakawa, Sami J. Barmada, Magdalena I. Ivanova, Henry L. Paulson Tags: PNAS Plus Source Type: research