Proteomic profiling of liver tissue from the mdx - 4cv mouse model of Duchenne muscular dystrophy

ConclusionsThe proteomic results presented here indicate that the intricate and multifaceted pathogenesis of themdx-4cv model of dystrophinopathy is associated with secondary alterations in the liver affecting especially fatty acid transportation. Since FABP5 levels were also shown to be elevated in serum from dystrophic mice, this protein might be a useful indicator for monitoring liver changes in X-linked muscular dystrophy.
Source: Clinical Proteomics - Category: Biochemistry Source Type: research