Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis

We describe that Fas/S1P1 signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis.
Source: Japanese Dental Science Review - Category: Dentistry Source Type: research

Related Links:

Publication date: Available online 17 January 2020Source: Biological ControlAuthor(s): Shunsuke Haraguchi, Toyoshi YoshigaAbstractTogether with several fungi, the plant parasitic nematode Ditylenchus destructor is among the pathogens that cause serious damage to garlic production areas in Japan. Because D. destructor is a plant and fungal feeder, its infestation may be influenced by the garlic plant-associated fungi and suppressed through control of those fungi. However, no information is currently available regarding the interaction between the nematode and the fungi. Aphelenchus avenae is a non-parasitic fungivorous nema...
Source: Biological Control - Category: Biology Source Type: research
BACKGROUND: A video that simulates the anatomical mechanism of shaking the infant head, which may have a stronger impact on the viewer, and a tool to prevent self-reported smothering in response to crying, has never been investigated. OBJECTIVE: To...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Conclusion: PsA is characterized by an increase in cardiovascular morbidity in relation with insulin resistance. Current treatments seem to improve this risk with a decrease in cardiovascular mortality in comparison with patients with plaque psoriasis but this requires confirmation in larger prospective studies.
Source: Joint Bone Spine - Category: Orthopaedics Source Type: research
This study focused specifically on sepsis patients admitted to a single Japanese ICU, and aimed to develop novel equations to estimate their total energy expenditure. A total of 95 sepsis patients were included in this study. We measured resting energy expenditure (REE) by using indirect calorimetry, and created equations to calculate basal metabolic rate (BMR) using height, weight and age as variables. REE was predicted by multiplying BMR by the novel equation with the stress factor of 1.4. The prediction error of our novel equations were smaller than those of other conventional equations. We further confirmed the accurac...
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
ConclusionOrofacial pain is a common complaint among the patients that come to a dentistry appointment, which may have different diagnosis and treatments. A positive effect on the patient’s symptomatology was confirmed clinically on subsequent dental appointments and monitored by infrared thermography.
Source: Journal of Oral Biology and Craniofacial Research - Category: Dentistry Source Type: research
Discussion: Japan's new HTA program is a first step toward development of a universal healthcare system that can be sustainable for many years into the future. Currently, Japan's HTA program requires provision of incremental cost-effectiveness ratios (ICERs) as evidence, with quality-adjusted life years as the preferred measure. Prices can be adjusted both upward and downward according to the degree of the ICER estimate. Japan is the first country to have adopted an algorithmic method for 'ICER-based' pricing; however, HTA measures that extend beyond a single ICER estimate are needed to take full advantage of HTA in the fu...
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
Publication date: Available online 16 January 2020Source: Journal of Hazardous MaterialsAuthor(s): Jianhong Li, Shan-Li Wang, Jingmin Zhang, Lirong Zheng, Dongliang Chen, Zhipeng Wu, Sabry M. Shaheen, Jörg Rinklebe, Yong Sik Ok, Hailong Wang, Weidong WuAbstractCoconut-fiber biochar (CFB) was applied at 3% (w/w) to two soils spiked with 250, 2500, 5000 mg kg−1 of lead (Pb), respectively, aiming to explore the effects of CFB and the significance of iron (Fe) plaque on rice roots on the accumulation and translocation of Pb in rice plants using micro-X-ray fluorescence and X-ray absorption spectroscopi...
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
A new virus found in Wuhan, China, has killed a small number of people in the country. The virus has also been detected in Japan and Thailand.
Source: CNN.com - Health - Category: Consumer Health News Source Type: news
ConclusionsThe costs of healthcare-associated infection outbreaks of antimicrobial-resistant bacteria can be significant. The productivity loss was much greater than the containment costs. Therefore, hospitals should meet the costs for prevention of these outbreaks.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
In this study, we focus on two types of water channels, aquaporin 3 (AQP3) and AQP5, in alveolar and ductal MECs before and after parturition. AQP3 showed diffuse localization in the cytoplasm of ductal MECs but concentrated localization in the basolateral membrane of alveolar MECs during the late pregnancy and lactation periods. Translocation of AQP5 from the cytoplasm toward the apical membrane occurred in ductal MECs immediately before parturition. Subsequently, we examined the hormonal influences on the expression of AQP3 and AQP5 in cultured MECs in vitro. Progesterone and estrogen distinctly increased AQP3 and AQP5 i...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
More News: Arthritis | Dentistry | Japan Health | Rheumatoid Arthritis | Rheumatology | Science | Study | Temporomandibular Disorders | Translocation