LMO7 and LIMCH1 interact with LRIG proteins in lung cancer, with prognostic implications for early-stage disease

The leucine-rich repeats and immunoglobulin-like domains (LRIG) proteins 1, 2 and 3 are integral membrane proteins that play important roles in human cancer [1]. The mRNA expression of LRIG1 is down-regulated in squamous cell carcinoma of the lung [2] as well as several other cancer types [3 –5]. High levels of LRIG1 in tumor tissue have been associated with better patient survival in several different tumor types such as squamous cell carcinoma and adenocarcinoma of the uterine cervix [4,6], breast cancer [7–9] and lung cancer [7,10].

Source: Lung Cancer - September 24, 2018 Category: Cancer & Oncology Authors: Terese Karlsson, Samuel Kvarnbrink, Camilla Holmlund, Johan Botling, Patrick Micke, Roger Henriksson, Mikael Johansson, H åkan Hedman Source Type: research