Role of double knockdown of tPA and MMP-9 on regulating the left ventricular function and remodeling followed by transverse aortic constriction-induced hypertrophic cardiomyopathy in mice.

In conclusion, although tPA-/-/MMP-9-/- seemed to preserve cardiac function in an experimental setting of hypertrophic cardiomyopathy at an early stage, it failed to exert long-term protective effect. PMID: 30323866 [PubMed]

https://www.ncbi.nlm.nih.gov/pubmed/30323866?dopt=Abstract

Source: American Journal of Translational Research - October 17, 2018 Category: Research Tags: Am J Transl Res Source Type: research