Formulation and evaluation of neuroactive drug loaded chitosan nanoparticle for nose to brain delivery: In-vitro characterization and In-vivo behavior study.

Formulation and evaluation of neuroactive drug loaded chitosan nanoparticle for nose to brain delivery: In-vitro characterization and In-vivo behavior study. Curr Drug Deliv. 2018 Oct 11;: Authors: Qureshi M, Aqil M, Imam SS, Ahad A, Sultana Y Abstract The present work was designed to explore the efficacy of neuroactive drug (risperidone) loaded chitosan lipid nano particle (RIS-CH-LNPs) to enhance the bioactivity in schizophrenia via nasal route. The three-factor and three-level formulation by design approach was used for optimization and their effects were observed on (Y1) size in nm, (Y2) % drug loading, and (Y3) % drug release. The optimized formulation RIS-CH-LNPopt was further evaluated for its surface morphology, ex-vivo permeation study, in-vivo behavior study, and stability study. The developed RIS-CH-LNPs showed nanometric size range with high drug loading and prolonged drug release. The optimized formulation (RIS-CH-LNPopt) has shown the particle size (132.75 nm), drug loading (7.64 %), drug release (80.72 %) and further ex-vivo permeation study showed 2.32 fold enhancement over RIS-SUS(suspension). In-vivo behavior studies showed that RIS-CH-NLCopt able to show significant greater bio-efficacy as compared to RIS-SUS [intranasal (i.n), intravenous (i.v)]. The pharmacokinetic and brain/plasma ratio of developed chitosan nanoparticle was higher at all time-points as compared to RIS-SUS either given by intranasal or intraveno...
Source: Current Drug Delivery - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Deliv Source Type: research