Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma.

Intraocular involvement is associated with a high risk of disease relapse in primary central nervous system lymphoma. Oncol Rep. 2018 Oct 11;: Authors: Zhuang L, Lai J, Chen K, Ding T, Yuan Y, Ma Y, Kang H, Lin Z, Fan N, Ma J, Zeng Q, Xu X, Wang Q, Chen B Abstract The aim of the present study was to prospectively evaluate the recurrence and survival outcome of primary central nervous system lymphoma (PCNSL) with intraocular involvement. For this purpose, a prospective cohort of 103 pathologically confirmed patients with PCNSL was enrolled in this study. Ophthalmologic examinations were performed both at diagnosis and during follow‑up. The patients with PCNSL with suspected intraocular involvement underwent vitrectomy for confirmation. Patients who presented with intraocular involvement either at diagnosis or during disease progression were allocated to the intraocular lymphoma (IOL) group. All patients with PCNSL received systemic methotrexate (MTX)‑based chemotherapy with or without radiotherapy. MTX intravitreal injection combined with systemic MTX‑based chemotherapy was recommended once ocular lesions were confirmed. Recurrent intraocular and central nervous system (CNS) events, progression‑free survival (PFS) and overall survival (OS) outcomes were analyzed. The findings of this study revealed that 21 patients with PCNSL exhibited intraocular involvement. One patient with IOL presented with isolated ocular lymphoma at th...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research