Epigenetics in Amyotrophic Lateral Sclerosis: A Role for Histone Post Translational Modifications in Neurodegenerative Disease

Amyotrophic Lateral Sclerosis (ALS) is the third most common adult onset neurodegenerative disorder worldwide. It is generally characterized by progressive paralysis starting at the limbs ultimately leading to death caused by respiratory failure. There is no cure and current treatments fail to slow the progression of the disease. As such, new treatment options are desperately needed. Epigenetic targets are an attractive possibility because they are reversible. Epigenetics refers to heritable changes in gene expression unrelated to changes in DNA sequence.
Source: Translational Research - Category: Research Authors: Source Type: research