Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice [Neuroscience]
Fragile X syndrome (FXS) is the most frequent form of heritable intellectual disability and autism. Fragile X (Fmr1-KO) mice exhibit aberrant dendritic spine structure, synaptic plasticity, and cognition. Autophagy is a catabolic process of programmed degradation and recycling of proteins and cellular components via the lysosomal pathway. However, a role...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jingqi Yan, Morgan W. Porch, Brenda Court-Vazquez, Michael V. L. Bennett, R. Suzanne Zukin Tags: PNAS Plus Source Type: research
More News: Academies | Autism | Brain | Disability | Fragile X Syndrome | Legislation | Neurology | Science