Outcomes with Ambulatory Advanced Heart Failure from the Medical Arm of Mechanically Assisted Circulatory Support (MedaMACS) Registry

Background: The outlook for ambulatory patients with advanced heart failure (HF) and the appropriate timing for left ventricular assist device (LVAD) or transplant remain uncertain. The aim of this study was to better understand disease trajectory and rates of progression to subsequent LVAD therapy and transplant in ambulatory advanced HF.Methods: Patients with advanced HF who were NYHA class III-IV and Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) Profiles 4-7 despite optimal medical therapy (without inotropic therapy) were enrolled across 11 centers and followed for the end-points of survival, transplantation, LVAD placement, and health-related quality of life.

Source: The Journal of Heart and Lung Transplantation - October 1, 2018 Category: Transplant Surgery Authors: Amrut V. Ambardekar, Michelle M. Kittleson, Maryse Palardy, Maria M. Mountis, Rhondalyn C. Forde-McLean, Adam D. DeVore, Salpy V. Pamboukian, Jennifer T. Thibodeau, Jeffrey J. Teuteberg, Linda Cadaret, Rongbing Xie, Wendy Taddei-Peters, David C. Naftel, J Source Type: research