Immunoblot reactivity at follow-up in treated patients with Lyme neuroborreliosis and healthy controls

Publication date: Available online 26 September 2018Source: Ticks and Tick-borne DiseasesAuthor(s): R. Dersch, A. Sarnes, M. Maul, O. Minakowski, T. Hottenrott, O. Stich, S. RauerAbstractAbout 5–20% of the general population in endemic areas have seroprevalence for anti-borrelial antibodies. Previous studies have shown a high rate of 25–97% of persisting anti-borrelial antibodies in patients with treated Lyme neuroborreliosis (LNB) at follow-up. These studies used immunoblots with antigens from whole-cell sonicates, which could be less specific than modern recombinant antigens. We assessed the seroprevalence of anti-borrelial antibodies in serum from patients with definite LNB and healthy controls with a line immunoblot using highly specific recombinant antigens.We retrospectively identified patients with treated definite LNB who were treated at the Medical Center–University of Freiburg. Serum from LNB patients at a mean follow-up period of 4.9 years (SD: 3.3) and serum from healthy controls were assessed for anti-borrelial antibodies with a line immunoblot with recombinant antigens.A total of 45 patients with definite LNB and 40 healthy controls were included. Ten LNB patients (22.7%) had persisting antibodies (IgG and/or IgM) in serum at follow-up. Serum samples from six healthy controls (15%) were positive for anti-borrelial antibodies (IgG and or IgM). Prevalence of positive IgM or IgG antibodies showed no statistically significant difference between LNB...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research

Related Links:

This study assessed cost-effectiveness of a potential anti-tick vaccine that would protect against both Lyme borreliosis (LB) and tick-borne encephalitis (TBE) in a highly endemic setting of Slovenia.A Markov model was developed to estimate cost-effectiveness of a vaccine with potential combined protection against LB and TBE from the societal perspective. The model expressed time in annual cycles, followed a target population through their lifetime, and applied an annual discounting of 3%. A target population entered the model in a susceptible state, with time dependent probabilities to acquire LB/TBE. Disease manifestatio...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
Conclusions: Our results confirm national trends suggesting increasing rates of TBI and substantially increased testing. This may reflect a greater incidence of TBI in our region and/or increased awareness of these infections. PMID: 30032283 [PubMed - as supplied by publisher]
Source: American Journal of Clinical Pathology - Category: Pathology Authors: Tags: Am J Clin Pathol Source Type: research
This study shows that humus type can be indicative of nymph abundance. Three types of humus were observed: (1) moder, (2) mull, and (3) mull-moder humus. One of them, moder humus, which is characterized by a thick layer of fragmented leaves, was found in multivariate analyses to be strongly associated with the nymph abundance. This study demonstrates that factors such as saturation deficit do not suffice to explain the differences in nymph abundance among sites. The composition of the soil and especially the type of humus should also be taken into consideration when assessing acarological risk.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
CONCLUSIONS AND IMPLICATIONS FOR PUBLIC HEALTH PRACTICE: Vectorborne diseases are a large and growing public health problem in the United States, characterized by geographic specificity and frequent pathogen emergence and introduction. Differences in distribution and transmission dynamics of tickborne and mosquitoborne diseases are often rooted in biologic differences of the vectors. To effectively reduce transmission and respond to outbreaks will require major national improvement of surveillance, diagnostics, reporting, and vector control, as well as new tools, including vaccines. PMID: 29723166 [PubMed - in process]
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
CONCLUSIONS: Our data reported an high percentage of Lyme Disease infection (19%) in non endemic area. The definition of a multidisciplinary working group and a clinical care pathway allowed a better clinical management of Lyme disease cases treated in Sacco Hospital, Milan. PMID: 29600690 [PubMed - as supplied by publisher]
Source: Giornale Italiano di Dermatologia e Venereologia - Category: Dermatology Tags: G Ital Dermatol Venereol Source Type: research
This study shows that humus type can be indicative of nymph abundance. Three types of humus were observed: (1) moder, (2) mull, and (3) mull-moder humus. One of them, moder humus, which is characterized by a thick layer of fragmented leaves, was found in multivariate analyses to be strongly associated with the nymph abundance. This study demonstrates that factors such as saturation deficit do not suffice to explain the differences in nymph abundance among sites. The composition of the soil and especially the type of humus should also be taken into consideration when assessing acarological risk.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
A constant increase in the incidence of tick-borne diseases has been observed in Europe since the last decade of the twentieth century. In Poland, the most common zoonoses transmitted by Ixodes ricinus ticks are tick-borne encephalitis (TBE) and Lyme disease. These diseases have become a serious clinical problem, especially in Podlaskie Region, which is considered an endemic area for these diseases (Czupryna et al., 2011).
Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Conclusions This study confirms that subclinical Borrelia seroconversion is common in south-eastern Sweden. The findings further suggest that male sex, younger age together with B. gariniii induced levels of IL-10, IL-17A and CCL20 may be associated with a subclinical course.
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In the summer of 2016, Jerome Goddard, a medical entomologist in Mississippi, received an email from the U.S. Centers for Disease Control and Prevention (CDC) with a desperate ask. The agency was conducting an “urgent” search for insect scientists around the U.S. who could take up to a six-month paid leave from work to help the CDC fight the Zika outbreak in the U.S., and possibly respond to areas with local transmission if needed. “That’s how bad it is—they need to borrow someone,” says Goddard, an extension professor of medical entomology at Mississippi State University. “We can&...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news
Publication date: Available online 3 February 2018 Source:Ticks and Tick-borne Diseases Author(s): Benjamin Cull, Maaike E. Pietzsch, Kayleigh M. Hansford, Emma L. Gillingham, Jolyon M. Medlock Public Health England’s passive Tick Surveillance Scheme (TSS) records the distribution, seasonality and host associations of ticks submitted from across the United Kingdom (UK), and helps to inform the UK government on emerging tick-borne disease risks. Here we summarise data collected through surveillance during 2010–2016, and compare with previous TSS data from 2005 to 2009, particularly in relation to the primary Ly...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
More News: Brain | Endemics | Lyme Disease | Neurology | Statistics | Study | Tickborne Diseases | Zoology