Mir-206 partially rescues myogenesis deficiency by inhibiting CUGBP1 accumulation in the cell models of myotonic dystrophy.

CONCLUSIONS: Ectopic miR-206 mimicking the endogenous temporal patterns specifically drives a myocyte program that boosts myoblast lineages, likely by promoting the expression of MyoD to rectify the myogenic deficiency by stimulating the accumulation of Celf1. ABBREVIATIONS: DMPK: (dystrophia myotonica protein kinase); 3'-UTR: (3'-untranslated region); MBNL1: (muscleblind-like [Drosophila]); DM1: (myotonic dystrophy type 1); GFP: (green fluorescent protein); RT-PCR: (quantitative reverse transcriptase-polymerase chain reaction); shRNA: (short hairpin RNA). PMID: 30281408 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/30281408?dopt=Abstract

Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research