Dynorphin / Kappa-opioid receptor control of dopamine dynamics: implications for negative affective states and psychiatric disorders.

Dynorphin / Kappa-opioid receptor control of dopamine dynamics: implications for negative affective states and psychiatric disorders.
Brain Res. 2018 Sep 19;:
Authors: Tejeda HA, Bonci A
Abstract
Negative affective states are prevalent symptoms in a plethora of neuropsychiatric disorders, including depression and drug addiction. Dysfunction of mesocorticolimbic dopamine systems has been implicated in negative affective states in neuropsychiatric disorders. The dynorphin / kappa-opioid receptor system is a powerful effector of stress-related behavior and is highly enriched within the mesocorticolimbic dopamine system. Dysfunction of dynorphin/KOR signaling within the mesocorticolimbic dopamine system is implicated in promoting symptoms in neuropsychiatric disorders. As such, the kappa-opioid receptor system provides an important therapeutic target to treat negative affective states associated with psychiatric disorders. In this review, we provide a comprehensive overview of the dynorphin / kappa-opioid receptor system and its role in regulating the mesocorticolimbic dopamine system, motivation, and emotional behavior. Furthermore, we highlight unresolved issues in the field and offer some insights for future research.
PMID: 30244022 [PubMed - as supplied by publisher]

Source: Brain Research - September 19, 2018 Category: Neurology Authors: Tejeda HA, Bonci A Tags: Brain Res Source Type: research