The allo-HLA-DP restricted T cell repertoire provoked by allogeneic dendritic cells contains T cells that show restricted recognition of hematopoietic cells including primary malignant cells.

In this study we elucidated that the allo-HLA-DP restricted T cell repertoire contained T cells with differential cell-lineage-specific recognition profiles. As expected, part of the allo-HLA-DP restricted T cells showed broad recognition of a variety of hematopoietic and non-hematopoietic cell types expressing the targeted mismatched HLA-DP allele. However, a significant proportion of the allo-HLA-DP restricted T cells showed restricted recognition of hematopoietic cells, including primary malignant cells, or even restricted recognition of only myeloid cells, including dendritic cells and primary acute-myeloid-leukemia samples, but not of other hematopoietic and non-hematopoietic cell types. These data demonstrate that the allo-HLA-DP specific T cell repertoire contains T cells that show restricted recognition of hematopoietic cells, which may contribute to specific graft-versus-leukemia effect reactivity without coinciding graft-versus-host disease. PMID: 30237261 [PubMed - as supplied by publisher]
Source: Haematologica - Category: Hematology Authors: Tags: Haematologica Source Type: research