GxE effects of FKBP5 and traumatic life events on PTSD: A meta-analysis

Recent findings from the World Mental Health Survey Consortium confirm that traumatic events are common, with over 70% of individuals endorsing at least one lifetime traumatic event and approximately one third endorsing four or more traumatic events (Benjet et al., 2016). Among a national sample of U.S. adults, 89.7% were exposed to at least one traumatic event, with 8.3% of exposed individuals reporting posttraumatic stress disorder (PTSD) during their lifetime (Kilpatrick et al., 2013). PTSD increases risk for a number of significant deleterious psychological (e.g., depression, substance use disorders, anxiety; Sareen et al., 2007), physical (e.g., respiratory and cardiovascular diseases, chronic pain; Sareen et al., 2007), and psychosocial (e.g., unemployment and marital instability; Kessler, 2000) health outcomes, highlighting a great need for identification of risk and resilience factors related to the etiology of PTSD.

Source: Journal of Affective Disorders - September 21, 2018 Category: Neurology Authors: Sage E. Hawn, Christina M. Sheerin, Mackenzie J. Lind, Terrell A. Hicks, Marisa E. Marraccini, Kaitlin Bountress, Silviu-Alin Bacanu, Nicole R. Nugent, Ananda B. Amstadter Source Type: research