The Placebo Effect Is Real, and Scientists May Be Able To Predict Who Responds

It’s well-established that placebo treatments, such as sugar pills, can prompt real reductions in symptoms for patients. But scientists have long struggled to understand exactly how the placebo effect works, and for whom. A small new study published in Nature Communications found that when some people with chronic back pain took a placebo sugar pill, their pain was reduced about as effectively as it would have been with pain medication. But the more novel finding, researchers say, is that people with certain traits reliably responded better to placebos than others — which could someday have significant implications for medical practice. “The standard line has been that placebo response is real, but it is not predictable,” says study co-author A. Vania Apkarian, a professor of physiology at Northwestern University’s Feinberg School of Medicine. “That’s the classic viewpoint in the literature: that you cannot predict who will respond or how much they will respond. In fact, we can predict both of them.” Apkarian and his colleagues recruited 63 patients with chronic back pain for the study. Forty-three were given a sugar pill that they didn’t know was a placebo, and 20 got no treatment at all. No one received an actual painkiller. Over the course of about eight weeks, the individuals had periodic laboratory assessments, and tracked their daily pain on a smartphone app. About half of the patients who received the sham treatme...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime Innovation Health Research Source Type: news

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Condition:   Chronic Lower Back Pain Intervention:   Device: PICO G2 4k Sponsors:   Cedars-Sinai Medical Center;   National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Journal of Orthopaedic&Sports Physical Therapy,Volume 50, Issue 6, Page 301-308, June 2020.
Source: The Journal of Orthopaedic and Sports Physical Therapy - Category: Physiotherapy Authors: Source Type: research
CONCLUSION: On the basis of a broadly based research and participatory development process, a set of indicators has been developed that enables comprehensive evaluation of the regional quality of care of cross-indication, integrated care models focusing on common diseases. In order to be able to increasingly evaluate aspects of care coordination and patient orientation, health promotion as well as nursing, palliative and emergency care in the future, it would be helpful if routine data were collected or made accessible in these areas as well. PMID: 32467041 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Evidenz, Fortbildung und Qualitat im Gesundheitswesen - Category: Health Management Tags: Z Evid Fortbild Qual Gesundhwes Source Type: research
This study aimed to evaluate lumbar lordosis during sit-to-stand (STS) and stand-to-sit (SIT) in individuals with and without chronic nonspecific low back pain (CNLBP). The second objective was to investigate sex-related differences in lumbar lordosis.
Source: Journal of Manipulative and Physiological Therapeutics - Category: Complementary Medicine Authors: Source Type: research
Conditions:   Pain;   Pain, Chronic;   Pain, Back Intervention:   Device: Soovu Labs Inc. Pain Relief System Sponsor:   Carewave Medical, Inc. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: The results revealed that activation of mGluR8 in PAG is not capable of improving the thermal hyperalgesia threshold. Based on the decreased expression of mGluR8 after SCI induced by clip compression injury and its significant increase after treatment of siRNA against mGluR8, this method might still hold promise as an effective treatment of neuropathic pain. It can be concluded that increased expression of mGluR8 is due to the fact that DCPG prevents the death of neurons that express these receptors. PMID: 32460469 [PubMed - as supplied by publisher]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
Chronic pain can have a devastating impact and lead to patient isolation. Many people with chronic pain are predisposed to anxiety-depressant symptoms, due to a lower quality life. The aim of the study is to demonstrate how neuromodulation methods, can encourage the reduction of chronic pain and an improvement in the quality of life, therefore advancing the restoration of psychological well-being. We involved 50 patients with a diagnosis of pain that not respond to traditional pharmacological therapies. Interventions: All subject had depression and anxiety symptoms and a low-quality life. We used the spinal cord stimulati...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Quality Improvement Study Source Type: research
AbstractInjured somatosensory nervous system cause neuropathic pain which is quite difficult to treat using current approaches. It is therefore important to find new therapeutic options. We have analyzed cedrol effect on chronic constriction injury (CCI) induced neuropathic pain in rats. The mechanical and thermal hypersensitivity were evaluated using the von Frey filament, radiant heat and acetone drop methods. The changes in the levels of biomarkers of oxidative stress including malondialdehyde (MDA) and total thiol (SH), as well as inflammatory mediators including Tumour Necrosis Factor alpha (TNF- α) and Interleu...
Source: Metabolic Brain Disease - Category: Neurology Source Type: research
AbstractPurpose of ReviewThe purpose of this narrative review is to inform readers of the particular impact opioids have had on midlife women and to provide perspective on non-opioid treatment options for women with chronic low back pain.Recent FindingsResearch has shown that midlife women experience more chronic low back pain than men and other age groups of women. As a result, opioids have been particularly deleterious in this demographic group. In addition, there are no data to recommend them for long-term use, while there is a breadth of data on the negative consequences of long-term opioid use. Treatment guidelines no...
Source: Current Obstetrics and Gynecology Reports - Category: OBGYN Source Type: research
Condition:   Chronic Low-back Pain Intervention:   Other: non interventional Sponsor:   University Hospital, Angers Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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