Epigenomic Control of Cardiac Fibrosis by Bet Bromodomain Proteins in Dilated Cardiomyopathy

Pathologic gene expression is a hallmark of DCM. Mice carrying a human DCM mutation in phospholamban (PLNR9C) develop fibrosis, DCM, HF and premature death. RNAseq showed fibrotic gene expression to be a key early driver of DCM in PLNR9C mice. Recently, bromodomain and extraterminal (BET) epigenetic reader proteins have been identified as key regulators of pathologic gene expression in the heart. Using a chemical genetic strategy, we studied the role of BET proteins on the temporal regulation of gene expression in DCM.

Source: Journal of Cardiac Failure - August 1, 2018 Category: Cardiology Authors: Michael A. Burke, Hiroko Wakimoto, Zhe Jiao, Joshua M. Gorham, Steven R. DePalma, David A. Conner, Jun Qi, Jonathan G. Seidman, James E. Bradner, Jonathan D. Brown, Saptarsi M. Haldar, Christine E. Seidman Tags: 001 Source Type: research