A Cardiac-Specific Regulatory Genetic Variant for Protein Kinase C α is Significantly Associated with Mortality in Patients with Heart Failure

Protein kinase C α (PRKCA) is a fundamental regulator of beta-adrenergic signaling and cardiac contractility. Previous studies suggested that increased cardiac expression of PRKCA is associated with adverse cardiac outcomes. Cardiac expression of PRKCA is partly genetically regulated, with the recently identified r s9909004 (T→C) as the most likely regulatory variant in failing human heart tissue, but the clinical impact of rs9909004 genotype remains unknown. Therefore the objectives of this study were to determine whether PRKCA rs9909004 genotype is associated with mortality in patients with heart failure a nd reduced ejection fraction (HFrEF), and if so, whether the genotype effects are modified by beta-blocker (BB) exposure.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 003 Source Type: research