Editorial Comment

Arterial hypertension and hypercholesterolemia are considered risk factors for hormonal testicular function and spermatogenesis. The authors performed an experimental study to determine whether drugs that block RAS at different levels could affect steroidogenesis in hypertensive mice due to HED. Three drugs were used, including the renin inhibitor aliskiren, the ACE inhibitor enalapril and the AT1R blocker losartan. Study parameters were the serum concentration of cholesterol, triglycerides, testosterone, estradiol and LH, and the gene and protein expression of aromatase, StAR and LH-r.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Investigative Urology Source Type: research