Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET.

Dynamic Exercise Elicits Dissociated Changes Between Tissue Oxygenation and Cerebral Blood Flow in the Prefrontal Cortex: A Study Using NIRS and PET. Adv Exp Med Biol. 2018;1072:269-274 Authors: Hiura M, Nariai T, Takahashi K, Muta A, Sakata M, Ishibashi K, Toyohara J, Wagatsuma K, Tago T, Ishii K, Maehara T Abstract Neuronal activity causes changes in both cerebral metabolic rate of oxygen (CMRO2) and cerebral blood flow (CBF). Since the relationship between tissue oxygenation and regional CBF (rCBF) during exercise has not been elucidated, we compared the data obtained using near-infrared spectroscopy (NIRS) and rCBF examined using positron emission tomography (PET). Participants in this study comprised 26 healthy young men. Changes in concentration of oxygenated hemoglobin (ΔO2Hb) and deoxygenated hemoglobin (ΔHHb) in the prefrontal cortex (PFC) were measured using NIRS continuously during a 15-min bout of the constant-load low-intensity cycling exercise (n = 14). Under the same protocol as the NIRS study, rCBF was measured using H215O and PET by the autoradiographic method at baseline (Rest) and at 3 min (Ex1) and 13 min (Ex2) after starting exercise (n = 12). As systematic factors influenced by exercise, heart rate, end-tidal pressure of carbon dioxide (PETCO2) and blood pressure (BP) were monitored. For each region investigated by NIRS, rCBF was analyzed quantitatively using PET-MRI co-registered standardized images. Desp...
Source: Adv Data - Category: Epidemiology Authors: Tags: Adv Exp Med Biol Source Type: research