Lenalidomide induced reversible parkinsonism, dystonia, and dementia in subclinical Creutzfeldt-Jakob disease

Prion diseases are neurodegenerative in nature and progress inexorably once clinical symptoms are evident [1]. Unlike thalidomide, lenalidomide rarely associates with neurotoxicicity. Up to now, thalidomide, but not lenalidomide, has been reported to be linked to acutely worsening Parkinson's disease [2]. Two cases have been reported with transient memory loss due to lenalidomide so far [3]. Here we describe a patient with reversible asymmetric parkinsonism, dystonia, and rapidly progressive dementia that appeared after administration of lenalidomide, and completely resolved shortly after its discontinuation.

Source: Journal of the Neurological Sciences - August 28, 2018 Category: Neurology Authors: H. Argente-Escrig, J.C. Martinez, E. G ómez, A. Balaguer, T. Sevilla, L. Bataller Tags: Letter to the Editor Source Type: research