Dexmedetomidine mitigates sevoflurane-induced cell cycle arrest in hippocampus

ConclusionSevoflurane suppressed neuron cell proliferation via inhibiting the expression of BDNF and TrkB, and DEX relieved the neurotoxicity induced by sevoflurane via α2 adrenergic receptor. These findings provided new evidence that DEX exerted as a neuroprotective strategy in sevoflurane-induced neuro-damage, and provided new basis for the clinical application of DEX.
Source: Journal of Anesthesia - Category: Anesthesiology Source Type: research