“Pure apathy” and cognitive dysfunctions in Parkinson’s disease: A meta-analytic study

Publication date: Available online 13 August 2018Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Alfonsina D’Iorio, Gianpaolo Maggi, Carmine Vitale, Luigi Trojano, Gabriella SantangeloAbstractParkinson’s Disease (PD) is characterized by motor and non-motor symptoms such as cognitive deficit and behavioural disturbances. Apathy seems to be related to cognitive impairment, but some studies failed to confirm the relationship due to different methodological procedures across studies. A meta-analysis on 8 studies was performed to explore the cognitive correlates of apathy without depression and dementia (pure apathy). Global cognitive function, memory, executive functions, processing speed/attention/working memory, visuospatial abilities and language were the outcomes. The effect size of the relationship between “pure apathy” and reduced global cognitive functioning, executive functions, processing speed/attention/working memory, visuospatial functions, long-term verbal memory was moderate, whereas apathy was strongly associated with inhibition dysfunctioning.Our results revealed a strong association between “pure apathy” and cognitive dysfunctions, particularly deficit of memory and executive functions related to altered prefronto-subcortical circuitries.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research

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Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons in the substantia nigra. However, other non-dopaminergic neuronal systems such as the serotonergic system are also involved. Serotonergic dysfunction is associated with non-motor symptoms and complications, including anxiety, depression, dementia, and sleep disturbances. This pathology reduces patient quality of life. Interaction between the serotonergic and other neurotransmitters systems such as dopamine, noradrenaline, glutamate, and GABA controls the activity of striatal neurons and are particularly interesting for understan...
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
Conclusions: Targeted interventions to address symptoms, functional status, and depression in patients with chronic diseases are needed.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Depression in dementia is common, with around half of people with Alzheimer's disease experiencing depression1,2, compared to prevalence rates of around a third in older adults without dementia3. The combined effect of depression with a disabling condition is profound, leading to reduced quality of life for people with dementia and their caregivers1, exacerbating cognitive and functional impairments4, increasing mortality5, and worsening care outcomes by increasing caregiver burden and risk of transition to residential care6,7.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Regular Research Article Source Type: research
CONCLUSION: For the majority of the physicians surveyed, psychiatry represented a public health priority, and their prioritising provides a probable explanation for their positive perception of their role in the management of mental disorders. However, we went on to observe that a number of difficulties constituted obstacles to their role in management of mental disorders and induced them to refer their patients to psychiatrists. Our analysis highlighted the impact of continuing education on physicians' attitudes and the interest of collaboration between practitioners. Efforts in university teaching and continuous educatio...
Source: Revue d Epidemiologie et de Sante Publique - Category: Epidemiology Tags: Rev Epidemiol Sante Publique Source Type: research
(Trinity College Dublin) Scientists at the Global Brain Health Institute (GBHI) at Trinity College Dublin have developed a new smartphone app to carry out a range of major research projects designed to tackle the brain basis of disorders of the mind, such as depression, anxiety and dementia.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
In conclusion, for individuals with dementia that reside in nursing homes, it seems like their MMSE score needs to change by four or more points between two measurements in order for their score change to be reliably higher than the measurement error.
Source: European Journal of Ageing - Category: Geriatrics Source Type: research
(Natural News) The use of anticholinergic medications is widespread, especially among older adults. These medications are often prescribed by physicians to treat a wide variety of health problems, including bladder disorders, gastrointestinal issues, seasonal allergies and even depression. However, recent studies have found a connection between the use of anticholinergic drugs and acute cognitive impairments. In particular, these...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Abstract The current study examined factors related to fatigue in family caregivers of individuals with dementia using a cross-sectional design to collect subjective and objective data. Findings indicated that caregivers' sleep quality, difficulty falling asleep, and depression, as well as care-recipients' functionality, were associated with family caregivers' fatigue. Regression analysis indicated that only sleep quality significantly predicted caregivers' fatigue. Study findings suggest fatigue is common among family caregivers of individuals with dementia and may be related to sleep quality. The level of fatigu...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
Abstract BACKGROUND: Centenarians escapers are those who reached 100 years of age without the diagnosis of any of the common age-related diseases and exploring their characteristics will inform about successful ageing. No previous study has examined centenarians free of common chronic diseases amongst New Zealand centenarians. METHODS: Retrospective observational cross-sectional review of a national dataset determining the prevalence of depression, dementia, diabetes and hypertension, smoking, physical activity and social relationships among older adults (aged 60-99 years) and centenarians. Particip...
Source: Aging Clinical and Experimental Research - Category: Geriatrics Authors: Tags: Aging Clin Exp Res Source Type: research
ConclusionsHHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities.
Source: Acta Diabetologica - Category: Endocrinology Source Type: research
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