Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static < sup > 18 < /sup > F-FDG PET as a function of injected dose.

Improved discrimination between benign and malignant LDCT screening-detected lung nodules with dynamic over static ¹⁸F-FDG PET as a function of injected dose.
Phys Med Biol. 2018 Aug 10;:
Authors: Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C
Abstract
Lung cancer mortality rate can be significantly reduced by up to 20% through routine low-dose computed tomography (LDCT) screening, which, however, has high sensitivity but low specificity, resulting in a high rate of false-positive nodules. Combining PET with CT may provide more accurate diagnosis for indeterminate screening-detected nodules. In this work, we investigated low-dose dynamic &lt;sup&gt;18&lt;/sup&gt;F-FDG PET in discrimination between benign and malignant nodules using a virtual clinical trial based on patient study with ground truth. Six patients with initial LDCT screening-detected lung nodules received 90-min single-bed PET scans following a 10 mCi FDG injection. Low-dose static and dynamic images were generated from under-sampled list-mode data at various count levels (100%, 50%, 10%, 5%, and 1%). A virtual clinical trial was performed by adding nodule population variability, measurement noise, and static PET acquisition start time variability to the time activity curves (TACs) of the patient data. We used receiver operating characteristic (ROC) anal...

Source: Physics in Medicine and Biology - August 10, 2018 Category: Physics Authors: Ye Q, Wu J, Lu Y, Naganawa M, Gallezot JD, Ma T, Liu Y, Tanoue L, Detterbeck F, Blasberg J, Chen MK, Casey M, Carson RE, Liu C Tags: Phys Med Biol Source Type: research