Solid-type poorly differentiated adenocarcinoma of the stomach: clinicopathological and molecular characteristics and histogenesis

We examined the expression of p53, mismatch-repair proteins, and mucin core glycoproteins; microsatellite status; and mutations inKRAS andBRAF, as well as clinicopathological features, in 54 cases of PDA of the stomach (31 solid-type PDAs and 23 non-solid-type PDAs).ResultsThe proportion (51.6%) of MSI in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5%) (p = 0.00022). The proportion of absent expression of MLH1 (58.1%) and PMS2 (51.6%) in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5 and 8%) (p 
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

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Conditions:   Melanoma;   Cervical Carcinoma;   Pancreatic Carcinoma;   Triple Negative Breast Cancer;   Hepatocellular Carcinoma;   Urothelial Carcinoma;   Squamous Cell Carcinoma of the Head and Neck;   Nasopharyngeal Carcinoma;   Renal Cell Carcinoma;   Colorectal Carcinoma;   E ndometrial Carcinoma;   Non-small Cell Lung Carcinoma;   Small Cell Lung Carcinoma;   Gastric or Gastroesophageal Junction Adenocarcinoma;   Advanc...
Source: - Category: Research Source Type: clinical trials
We report a patient with Crohn’s disease who was diagnosed with signet-ring cell carcinoma in the setting of a Crohn’s flare. Diagnosis was made with endoscopy. Treatment included laparoscopic-assisted right hemicolectomy with ileostomy with subsequent chemotherapy as an outpatient .Case Rep Gastroenterol 2019;13:85 –88
Source: Case Reports in Gastroenterology - Category: Gastroenterology Source Type: research
ConclusionsHigher MD adherence was associated with reduced risks of ESCC, GCA, and GNCA in the NLCS. However, the decreased ESCC risk might be limited to men.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
AbstractPrimary gastric squamous cell carcinoma (SCC) is a rare histological subtype of gastric cancer. Here, we report the first case of primary gastric verrucous carcinoma (VC), a well-differentiated variant of SCC. Gastroscopy revealed a papillary polypoid lesion at the posterior wall of the upper gastric body and isolated squamous epithelium at the greater curvature of the fornix in a 78-year-old woman. Endoscopic submucosal dissection was performed. Microscopically, the lesion comprised very well-differentiated squamous epithelium with minimal atypia and exhibited coarse papillary structure and bulbous epithelial down...
Source: Virchows Archiv - Category: Pathology Source Type: research
ConclusionsPDX models can be successfully created from clinical biopsy specimens in patients with metastatic or unresectable GI cancers. The use of clinical biopsy specimens for PDX engraftment can expand the repertoire of stage-specific PDX models for downstream basic/translational research.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
Authors: Wang C, Zhang Q, Hu Y, Zhu J, Yang J Abstract Digestive system malignancies are the most common cancer types worldwide and exhibit an extremely low overall 5-year survival rate. Therefore, clinically applicable biomarkers for predicting clinical outcome are urgently required. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is abnormally expressed in several cancer types. However, to the best of our knowledge, the association between MALAT1 expression and the prognosis of digestive system malignancies remains unknown. Therefore, the current study performed a meta-analysis to comprehensively ...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
CONCLUSIONS This study showed that HOTTIP acts as an oncogene in NPC by sponging miR-4301. PMID: 30685769 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract BACKGROUND: Gastric 'indefinite for neoplasm/dysplasia' (IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management. AIM: To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions. METHODS: In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection (n = 134), surge...
Source: World Journal of Gastroenterology : WJG - Category: Gastroenterology Authors: Tags: World J Gastroenterol Source Type: research
Publication date: Available online 18 January 2019Source: Inorganic Chemistry CommunicationsAuthor(s): Yi-Dong Bin, Yan Yang, Xu-Jian Luo, Hua-Xin ZhangAbstractA novel Pt(II) complex of [PtII(MPP)(OPD)]Cl⋅H2O (MPP-Pt) (OPD = o-phenylenediamine) with 2-(2,5-methoxy-phenyl) imidazo [4,5-f]-[1, 10] phenanthrolin (H-MPP) was synthesized and fully characterized. In MPP-Pt complex, the Pt(II) ion adopts a four-coordinated square planar geometry. MPP-Pt exhibited selective cytotoxicity against human carcinoma (A549), hepatoblastoma (Hep-G2), ovarian (SK-OV-3), cervical (HeLa) and gastric adenocarcinoma (MGC80–3) ce...
Source: Inorganic Chemistry Communications - Category: Chemistry Source Type: research
ConclusionsSEMA3B, SEMA3B-AS1, and miR-6872 may act as tumor suppressors and may serve as potential targets for antitumor therapy.
Source: Gastric Cancer - Category: Gastroenterology Source Type: research
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