Solid-type poorly differentiated adenocarcinoma of the stomach: clinicopathological and molecular characteristics and histogenesis

We examined the expression of p53, mismatch-repair proteins, and mucin core glycoproteins; microsatellite status; and mutations inKRAS andBRAF, as well as clinicopathological features, in 54 cases of PDA of the stomach (31 solid-type PDAs and 23 non-solid-type PDAs).ResultsThe proportion (51.6%) of MSI in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5%) (p = 0.00022). The proportion of absent expression of MLH1 (58.1%) and PMS2 (51.6%) in solid-type PDA was significantly higher than that in non-solid-type PDA (4.5 and 8%) (p 
Source: Gastric Cancer - Category: Gastroenterology Source Type: research

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Authors: Zheng P, Wang W, Ji M, Zhu Q, Feng Y, Zhou F, He Q Abstract Gastric cancer is the second major cause of death associated with cancer and ranks among the top four cancers diagnosed worldwide. Previous findings identified the association of transmembrane proteins (TMEMs) with tumorigenesis of various types of cancer, including breast, liver and kidney cancer. However, the expression and the biological function of TMEMs, especially TMEM119, and its possible molecular mechanism in gastric cancer remain less understood. CCK-8 and flow cytometric analysis was employed to examine the viability and apoptosis of ga...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
The use of Immune checkpoint inhibitors constitutes an emerging therapeutic field for the therapy of gastrointestinal (GI) malignancies following the recent FDA approvals of PD-1 inhibitors for esophago-gastric adenocarcinoma, hepatocellular carcinoma and for microsatellite-instable tumors, which are mainly colorectal cancers. This paper reviews the clinical evidence end of 2017 and discusses the clinical development programs of atezolizumab, avelumab, durvalumab, nivolumab and pembrolizumab in GI-tract cancers: since 2014, these antagonists of the PD-1/PD-L1 axis have gained approval for use in numerous other tumors.
Source: Critical Reviews in Oncology Hematology - Category: Cancer & Oncology Authors: Source Type: research
This study demonstrated that mancozeb was able to inhibit cell proliferation by 56–82% at 5–10 μM concentrations after 48 h. Mancozeb treatment for 48 h resulted in 33% (P 
Source: Mitochondrion - Category: Biochemistry Source Type: research
We report a case of a 71 year old man who was admitted with symptoms of obstructive jaundice and slight epigastric pain and weight loss. Clinical and histological investigations revealed a small (
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Publication date: October 2017Source: Best Practice &Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Jing Dong, Aaron P. ThriftAbstractOesophago-gastric cancers (oesophageal and gastric cancers) are common, highly fatal cancers. Oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC) are the two main histological subtypes of oesophageal cancer. Globally, OSCC remains the most common histological subtype of oesophageal cancer, with the highest burden occurring along two geographic belts, one from north central China through the central Asian republics to northern Iran, and one fr...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
We report a unique case of a MiNEN with trilineage differentiation: large-cell neuroendocrine carcinoma, squamous cell carcinoma, and adenocarcinoma. The reported patient presented with symptoms of an upper gastrointestinal bleed and was ultimately diagnosed with a MiNEN with trilineage differentiation. This is the first report of this exceedingly rare tumor type to include next-generation sequencing of the 3 separate tumor entities. In addition, we review the current literature and discuss the role of next-generation sequencing in classifying and treating MiNEN tumors. PMID: 29984070 [PubMed]
Source: Journal of Gastric Cancer - Category: Gastroenterology Tags: J Gastric Cancer Source Type: research
This study demonstrated that mancozeb was able to inhibit cell proliferation by 56–82% at 5–10 μM concentrations after 48 h. Mancozeb treatment for 48 h resulted in 33% (P 
Source: Mitochondrion - Category: Biochemistry Source Type: research
We report a case of a 71 year old man who was admitted with symptoms of obstructive jaundice and slight epigastric pain and weight loss. Clinical and histological investigations revealed a small (
Source: Human Pathology: Case Reports - Category: Pathology Source Type: research
Publication date: October 2017Source: Best Practice &Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Jing Dong, Aaron P. ThriftAbstractOesophago-gastric cancers (oesophageal and gastric cancers) are common, highly fatal cancers. Oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC) are the two main histological subtypes of oesophageal cancer. Globally, OSCC remains the most common histological subtype of oesophageal cancer, with the highest burden occurring along two geographic belts, one from north central China through the central Asian republics to northern Iran, and one fr...
Source: Best Practice and Research Clinical Gastroenterology - Category: Gastroenterology Source Type: research
Objective Gastric-type mucinous adenocarcinoma (GAS) of uterine cervix has been suggested as distinct clinicopathologic behavior. Our study aimed to investigate the distinguishing imaging features and clinical outcomes of GAS. Methods Fifteen cases of GAS and 45 cases of 3:1 age-matched usual-type endocervical carcinoma (UEA) were assessed. Clinical parameters (age, tumor size, clinical stage, and time to recurrence [TTR] or death) and pathologic results confirmed by surgery were recorded. Imaging features (tumor shape, margin, presence of vaginal involvement, or cyst) on magnetic resonance T2-weighed images were eval...
Source: International Journal of Gynecological Cancer - Category: Cancer & Oncology Tags: Cervical Cancer Source Type: research
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