FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients

The FDA warns of an increased risk for relapse of hematologic malignancy and for death when azithromycin is used to prevent bronchiolitis obliterans syndrome in hematopoietic stem cell transplant patients.News Alerts
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

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This study is complemented by another report that found that hRSV infection induces significant expression of three miRNAs, namely hsa-miR-4448, hsa-miR-30a-5p, and hsa-miR-4634 in human DCs (104). Interestingly, this latter study also performed comparative analyses of miRNA profiles between DCs infected with hRSV and a related virus, namely the human metapneumovirus, and found that both viruses induced the expression of elevated levels of hsa-miR-4634. Elucidating the contribution of these miRNAs in DCs in response to hRSV remains to be determined. Dendritic Cell Phenotype and Migration Upon hRSV Infection in vivo Altho...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Paraneoplastic pemphigus (PNP) occurs more often in patients with hematologic malignancies (HMs) than in patients with solid cancer. Lung bronchiolitis obliterans (BO) is a severe complication of PNP.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Tags: Original article Source Type: research
Graft-versus-host disease (GVHD) of the lung, also known as bronchiolitis obliterans syndrome (BOS), is associated with high mortality, but treatment with the combination of fluticasone, azithromycin, and montelukast (FAM) stabilizes lung function in the majority of patients. Recently, a randomized controlled trial evaluating azithromycin given at the time of conditioning for GVHD prevention was closed prematurely due to an increased risk of cancer relapse in azithromycin recipients. We evaluated whether exposure to azithromycin after allogeneic hematopoietic cell transplantation (allo-HCT), primarily for treatment of BOS,...
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Tags: 326 Source Type: research
CONCLUSION: IL-17A is a major regulator of inflammatory responses. In all the mentioned diseases, IL-17A plays a prime role in inducing the diseases, whereas the lack of this pro-inflammatory cytokine reduces the severity of respective respiratory diseases. Thereby, this review suggests IL-17A as an instrumental target in the chronic respiratory diseases. PMID: 30652654 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Conclusions: 1-Radiologists must consider SRIF on performing HRCT on smokers or ex-smokers. 2-SRIF may coexist with multiple HRCT patterns of smoking-related ILD TABLE 1-HRTC PATTERNPatientsUIP5Possible UIP1Inconsistent UIP3NSIP3RB-ILD5Pulmonary LCH2 TABLE 2-ILD diagnosisPatientsCPFE (RA-ILD)1CPFE (IPF)5CPFE (NSIP)1CPFE (HP)1CPFE (Unclassifiable IIP)1IPAF2RB-ILD5Unclassifiable IIP1Pneumoconiosis1RA-ILD1
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Rare ILD/DPLD Source Type: research
Background: Late pulmonary complications are common after aSCT. In a national cohort of young aSCT survivors, we aimed to assess very long-term effects of aSCT on pulmonary function.Patients and methods: In total, 104 patients (16 years at time of survey, 56% females) were examined>5 years after aSCT. Conditioning prior to aSCT comprised chemotherapy with busulphan and cyclophosphamide in all but two cases. Methods included measurements of static and dynamic lung volumes and gas diffusing capacity.Results: Mean (SD) age at aSCT and observation time were, respectively, 17.2 (9.3) years and 17.3 (5.6) years. For the entir...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
In this report, 3 transbronchial biopsies showed viral inclusions on histologic examination and were evaluated for anti-SV40 large T antigen (SV40 T Ag) by immunohistochemistry (IHC), in situ hybridization, and viral genome sequencing by polymerase chain reaction. Patients 1 and 2 were immunosuppressed lung transplant recipients. Patient 1 presented with diffuse pruritic rash and respiratory failure, and patient 2 with PyV viremia. Patient 3 had chronic lymphocytic leukemia/small lymphocytic lymphoma and presented with cough and shortness of breath. Histologic examination of all 3 lung biopsies were similar and revealed pr...
Source: Pathology Case Reviews - Category: Pathology Tags: Call for Papers 2017 Source Type: research
Abstract Currently, lung cancer is one of the most lethal types of cancer (IARC, 2012), the pathology being detected in advanced stage, when the tumor has considerable volume because the disease in most cases asymptomatic in the early stages (INCA, 2016). Dosimetry analysis of healthy organs under real conditions is not feasible. Therefore, computational simulations are used to aid in dose verification in organs of patients submitted to radiotherapy. The goal of this study was to calculate the equivalent dose, due to photons, in the surrounding of healthy organs of patients submitted to radiotherapy for lung cance...
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Tags: Appl Radiat Isot Source Type: research
Condition:   Other Cancer Intervention:   Drug: ruxolitinib Sponsors:   Massachusetts General Hospital;   Incyte Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Four-month-old Roman Hansen, from South Shields, was initially with  bronchiolitis until tests showed a collapsed lung, leading to him having much of the organ removed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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