FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients FDA: Don't Use Azithromycin for Lung Condition in Cancer Patients

The FDA warns of an increased risk for relapse of hematologic malignancy and for death when azithromycin is used to prevent bronchiolitis obliterans syndrome in hematopoietic stem cell transplant patients.News Alerts
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Hematology-Oncology News Alert Source Type: news

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In this report, 3 transbronchial biopsies showed viral inclusions on histologic examination and were evaluated for anti-SV40 large T antigen (SV40 T Ag) by immunohistochemistry (IHC), in situ hybridization, and viral genome sequencing by polymerase chain reaction. Patients 1 and 2 were immunosuppressed lung transplant recipients. Patient 1 presented with diffuse pruritic rash and respiratory failure, and patient 2 with PyV viremia. Patient 3 had chronic lymphocytic leukemia/small lymphocytic lymphoma and presented with cough and shortness of breath. Histologic examination of all 3 lung biopsies were similar and revealed pr...
Source: Pathology Case Reviews - Category: Pathology Tags: Call for Papers 2017 Source Type: research
Abstract Currently, lung cancer is one of the most lethal types of cancer (IARC, 2012), the pathology being detected in advanced stage, when the tumor has considerable volume because the disease in most cases asymptomatic in the early stages (INCA, 2016). Dosimetry analysis of healthy organs under real conditions is not feasible. Therefore, computational simulations are used to aid in dose verification in organs of patients submitted to radiotherapy. The goal of this study was to calculate the equivalent dose, due to photons, in the surrounding of healthy organs of patients submitted to radiotherapy for lung cance...
Source: Applied Radiation and Isotopes - Category: Radiology Authors: Tags: Appl Radiat Isot Source Type: research
Condition:   Other Cancer Intervention:   Drug: ruxolitinib Sponsors:   Massachusetts General Hospital;   Incyte Corp. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Four-month-old Roman Hansen, from South Shields, was initially with  bronchiolitis until tests showed a collapsed lung, leading to him having much of the organ removed.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Chronic graft-versus-host disease (cGVHD) is characterized as autoimmune-like fibrosis and antibody production mediated by pathogenic T cells and B cells. MicroRNA-17-92 (miR-17-92) influences the survival, differentiation, and function of lymphocytes in cancer, infections, and autoimmunity. To determine whether miR-17-92 regulates T- and B-cell responses in cGVHD, we generated mice conditionally deficient for miR-17-92 in T cells, B cells, or both. Using murine models of allogeneic bone marrow transplantation, we demonstrate that expression of miR-17-92 in donor T and B cells is essential for the induction of both sclerod...
Source: Blood - Category: Hematology Authors: Tags: Immunobiology and Immunotherapy, Transplantation Source Type: research
This study aimed to evaluate a reader-independent quantitative density metric (QDM) derived from CT histograms to associate with CLAD survival. A retrospective study evaluated CT scans corresponding to CLAD onset using pulmonary function tests in 74 patients (23 RAS, 51 BOS). Two different QDM values (QDM1 and QDM2) were calculated using CT lung density histograms. Calculation of QDM1 includes the extreme edges of the histogram. Calculation of QDM2 includes the central region of the histogram. Kaplan-Meier analysis and Cox regression analysis were used for CLAD prognosis. Higher QDM values were significantly associated wit...
Source: Clinical Lung Cancer - Category: Cancer & Oncology Authors: Tags: Clin Transplant Source Type: research
(MedPage Today) -- This week's topics include infants with bronchiolitis, orthotics for heel pain, behavioral therapy in dementia, and H. pylori infection in early gastric cancer
Source: MedPage Today Psychiatry - Category: Psychiatry Source Type: news
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Welcome to the 318th LITFL Review! Your regular and reliable source for the highest highlights, sneakiest sneak peeks and loudest shout-outs from the webbed world of emergency medicine and critical care. Each week the LITFL team casts the spotlight on the blogosphere’s best and brightest and deliver a bite-sized chunk of FOAM. The Most Fair Dinkum Ripper Beauts of the Week January is National Slavery and Human Trafficking month. Listen to this insightful podca...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: LITFL review LITFL R/V Source Type: blogs
We described a case of bronchiolitis obliterans organizing pneumonia after stereotactic ablative radiation therapy for a recurrent lung cancer. Antibiotics and steroids were administered to solve the clinical picture. After three years, a new lesion at the right lung was found and treated with stereotactic ablative radiation therapy and concomitant long course of steroids with no recurrence of bronchiolitis obliterans organizing pneumonia. Bronchiolitis obliterans organizing pneumonia is a rare event after radiotherapy with undefined risk factors. In our case, steroids played an important role in management and, maybe, in ...
Source: Cancer Radiotherapie - Category: Cancer & Oncology Authors: Tags: Cancer Radiother Source Type: research
Survival after lung transplantation (LTx) remains poor, mainly due to development of chronic lung allograft dysfunction. Daily immunosuppression is needed to decrease the host immune response but dosing and side effects remain troublesome. We hypothesize that underlying genetic differences in proteins involved in metabolisation of immunosuppression may interfere with post-transplant outcome.We investigated the relation between genetic variants of MMF transporters (rs2306283, rs4149056, rs4149015 and rs2306168) and outcome for our entire LTx population via recipient DNA extracted from blood/tissue, using TaqMan® OpenArr...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Transplantation Source Type: research
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