Quantification of motor neuron loss and muscular atrophy in ricin-induced focal nerve injury - Liang Y, Zhang J, Walczak P, Bulte JWM.

The objective of this study was...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news

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We examined long-term stress hormones and other stress markers in subjects three generations removed from the Holocaust, to assess the long-term consequences of inherited behavioral and physiological responses to prior stress and trauma. Jewish subjects who recalled overprotective parental behavior had higher hairsteroid-concentrations and dampened limbic-hypothalamic-pituitary-adrenal (LHPA) axis reactivity compared to German and Russian-German subjects with overprotective parents. We suggest that altered LHPA axis activity in maternally overprotected Jewish subjects may indicate a transmitted pathomechanism of "frus...
Source: Stress - Category: Research Tags: Stress Source Type: research
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease that occurs in 4 among 100 000 people in the United States. Individuals with ALS gradually lose their ability to control voluntary muscles, diminishing their ability to communicate. A comprehensive multidatabase search retrieved 31 qualitative research articles that addressed persons with end-of-life experiences with ALS. Inclusion/exclusion criteria were applied and a critical appraisal was applied for the final 8 included articles. First-person data extraction from the final articles represented emergence of 3 themes significant to persons with ALS: deci...
Source: Holistic Nursing Practice - Category: Nursing Tags: FEATURES Source Type: research
Conclusions:These data suggest sleep and pain are worst in Veterans with TBI and PTSD, and that sleep is similarly impaired in Veterans with PTSD despite not having as much pain. Thus, although this is a complex relationship, these data suggest PTSD may be driving sleep disturbances, and the added effect of TBI in the comorbid group may be driving pain in this population.Citation:Balba NM, Elliott JE, Weymann KB, Opel RA, Duke JW, Oken BS, Morasco BJ, Heinricher MM, Lim MM. Increased sleep disturbances and pain in Veterans with comorbid traumatic brain injury and posttraumatic stress disorder.J Clin Sleep Med. 2018;14(11):1865–1878.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusions:Elevated REI and lower sleep period RSA were independently predictive of NM/DD. The former result is consistent with studies showing that sleep-disordered breathing (SDB) is a factor in NM/DD, and that continuous positive airway pressure (CPAP) can reduce these symptoms in patients with comorbid PTSD and SDB. The latter result implicates dysregulated arousal modulation during sleep in trauma-related NM/DD. It is consistent with findings that NM/DD are reported in patients without SDB and can persist in patients with comorbid PTSD and SDB even when CPAP successfully remediates SDB.Citation:Miller KE, Jamison AL,...
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
CONCLUSIONS: PTSD is an important clinical consideration in older adults, although the empirical database, particularly regarding psychotherapy, is limited. CLINICAL IMPLICATIONS: Assessment for trauma history and PTSD symptoms in older adults is essential, and may lead to increased recognition and treatment. PMID: 30422749 [PubMed - as supplied by publisher]
Source: Clinical Gerontologist - Category: Geriatrics Tags: Clin Gerontol Source Type: research
She also investigated links between various disorders, like depression and smoking, and suggested that migraines could cause mental problems — and vice versa.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Breslau, Naomi Deaths (Obituaries) Post-Traumatic Stress Disorder Smoking and Tobacco Michigan State University Source Type: news
Mental illness can be notoriously difficult to diagnose in many cases, since symptoms may be invisible to physicians and those that are can be misleading. Objective methods that don’t rely on a direct observation would help to improve diagnosis...
Source: Medgadget - Category: Medical Devices Authors: Tags: Psychiatry Rehab Source Type: blogs
Conclusions: Despite some statistical instability of the results due to limitations in sample size, our study supports the role of CSF pNfH as a prognostic biomarker for motor neuron diseases presenting with UMN signs. A potential power to discriminate between ALS and other UMN syndromes at presentation, and between all of the examined MND and HC, has been detected for both CSF and serum pNfH.Neurodegener Dis 2018;18:255 –261
Source: Neurodegenerative Diseases - Category: Neurology Source Type: research
AbstractIntroductionThe progression of amyotrophic lateral sclerosis (ALS) leads to a decline of the nutritional status that represents an independent prognostic factor for survival. Recent studies recognize the muscle tissue as an endocrine organ able to release several molecules, called myokines. Among them, irisin seems to be involved in the regulation of metabolism, body weight and development and function of the nervous system.Objectives(1) To evaluate irisin serum levels in patients with ALS, with comparison to healthy subjects; (2) to assess the possible association of circulating irisin levels of ALS patients with ...
Source: Journal of Neurology - Category: Neurology Source Type: research
Chronic traumatic encephalopathy (CTE) is the neurodegenerative disease of the moment, made famous by the violent and untimely deaths of many retired professional athletes. Repeated blows to the head sustained in contact sports such asboxing and American football can result in abnormal accumulations oftau protein (usually many years later). The autopsied brains from two of these individuals are shown below.Left: courtesy of Dr. Ann McKee inNYT. Right: courtesy of Dr. Bennett Omalu inCNN. These are coronal sections1 from the autopsied brains of: (L) Aaron Hernandez, aged 27; and(R) Fred McNeill, aged 63.Part 1 of this ...
Source: The Neurocritic - Category: Neuroscience Authors: Source Type: blogs
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