Motor Neuron Disease: Pathophysiology, Diagnosis, and Management

Motor neuron diseases are the result of dysfunction of upper motor neurons in the precentral gyrus of the frontal lobe and/or lower motor neurons in the ventral horn of the spinal cord. In general, they cause weakness without notable sensory symptoms or pain. The most common motor neuron disease is amyotrophic lateral sclerosis, which is the primary focus of this review. Other motor neuron diseases include hereditary spastic paraparesis, spinobulbar muscular atrophy, and infectious motor neuron diseases including polio and West Nile virus.
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Review Source Type: research