Radiation Therapy Can Increase Mesothelioma Survival Time

Too many patients with malignant pleural mesothelioma are going without adjuvant radiotherapy that could extend their lives significantly, according to Dr. Bin Teh at Houston Methodist Hospital in Texas. Teh is the senior author of a recent study — the largest of its kind — that examined the role and extent of radiation therapy in the overall treatment of mesothelioma. He and his colleagues found only 3.1 percent of patients diagnosed with pleural mesothelioma underwent radiotherapy treatment in combination with aggressive surgery. “Surgery plus radiation improves overall survival,” Teh, vice chair of the Department of Radiation Oncology at Houston Methodist, told Asbestos.com. “I was surprised at how little it was used overall. I would really like to see more than 3 percent receiving this treatment safely.” National Cancer Database Numbers Their retrospective study was done by using the National Cancer Database (NCDB), a joint project of the American Cancer Society and the American College of Surgeons. It typically represents an estimated 70 percent of cancers nationwide. The study was published in the June issue of International Journal of Radiation Oncology. “The goal with radiation is to prevent disease from coming back after surgery,” Teh said. “With mesothelioma, it is really important to do it at a specialty center with experience.” Researchers went back more than two decades in the database to find 24,914 m...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news

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This study aimed to assess physical function and HRQOL of MPM patients following pleurectomy/decortication (P/D) in the convalescent phase.MethodsThe study included 16 male MPM patients who underwent P/D between September 2014 and August 2016. Physical function was assessed based on handgrip and knee extensor strengths, the six-minute walk distance (6MWD), and pulmonary function, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV1). HRQOL was assessed using the Medical Outcome Study 36-item Short Form Health Survey (SF-36). The assessment was performed preoperatively, postoperatively, and...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Publication date: Available online 18 October 2019Source: The Annals of Thoracic SurgeryAuthor(s): Joseph S. Friedberg, Charles B. Simone, Melissa J. Culligan, Mary E. Putt, Andrew R. Barsky, Sharyn Katz, Keith A. CengelABSTRACT:BackgroundPosterior intercostal lymph nodes, previously undescribed for cancer staging, are part of the lymphatic drainage of the pleural space. The purpose of this study was to assess the impact of posterior intercostal lymph nodes on survival in patients undergoing surgery for malignant pleural mesothelioma.MethodsAs part of the thoracic lymphadenectomy, posterior intercostal lymph nodes were acc...
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Sano M, Kaneko MK, Kato Y Abstract The highly O-glycosylated membrane glycoprotein podoplanin (PDPN) is frequently overexpressed in several malignant cancers, such as oral cancer, lung cancer, germinal neoplasia, mesothelioma, and brain tumor. The expression of PDPN is strongly associated with cancer progression and poor prognosis. PDPN possesses three tandem repeats of platelet aggregation-stimulating (PLAG) domains (PLAG1, PLAG2, and PLAG3) and PLAG-like domain (PLD), and binds to C-type lectin-like receptor 2 (CLEC-2) on platelets, followed by PDPN-mediated platelet aggregation. We have previously estab...
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Johnson &Johnson on Friday recalled a single batch of its baby powder as a precaution after government testing found trace amounts of asbestos in one bottle bought online. The recalled lot consists of 33,000 bottles which were distributed last year. J&J said the U.S. Food and Drug Administration found minuscule amounts of asbestos in one bottle during routine testing and notified the company on Thursday. J&J said it immediately began investigating with the FDA. “The FDA’s testing on prior occasions, and as recently as last month, found no asbestos,” said spokesman Ernie Knewitz. J&J said it was checki...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized onetime public health Source Type: news
Johnson &Johnson announced a voluntary recall on Friday of an estimated 33,000 bottles of its iconic baby powder after the U.S. Food and Drug Administration found traces of asbestos in a bottle purchased recently from an online retailer. The company also said that it was working closely with federal authorities to determine the validity of the test results and the integrity of the tested sample. FDA testing indicated sub-trace levels of chrysotile asbestos contamination, defined as no greater than 0.00002%, according to the announcement. Exposure to asbestos, a naturally occurring mineral and known carcinogen, is the p...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Food and Drug Administration tests found 'sub-trace' amounts of asbestos, a contaminant linked to cancer in a bottle of Baby Powder. J&J faces 13,000 lawsuits over mesothelioma from talc.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
This study was the first large case series to identify contaminated cosmetic talc as the cause of mesothelioma and the first to use background controls dictated by no known asbestos exposure. It emphasizes the continued risk from common cosmetic products once thought to be safe for all. “I would tell people that there is no regulation for talc, and that if there is a safer alternative, than I would advise them to do that,” Moline said. “I would not recommend people use talcum powder.” The post Case Study Shows Asbestos in Talc Causes Mesothelioma appeared first on Mesothelioma Center - Vital Service...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
Doctors at the Swiss Group for Clinical Cancer Research in Zurich, Switzerland, have uncovered a novel, anti-tumor compound that could become a needed second-line treatment for pleural mesothelioma cancer. Their recent multicenter phase II clinical trial conducted in Switzerland and Italy revealed the safety and efficacy of lurbinectedin, a synthetically produced agent that inhibits the growth of mesothelioma cells. “We believe this could represent a new treatment option for pleural mesothelioma,” Dr. Yannis Metaxas, oncologist at Kantonsspital Graubunden outside Zurich, told The Mesothelioma Center at Asbestos...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
A new 33-patient case study published in the Journal of Occupational and Environmental Medicine provides some of the strongest proof yet that exposure to asbestos-tainted talcum powder may cause malignant mesothelioma, a rare and deadly cancer that affects tissues lining internal organs. This isn’t only an important scientific discovery—it could also give new ammunition to plaintiffs in the thousands of cases brought against brands selling talcum-powder-based products alleged to cause cancer, like Johnson &Johnson’s Baby Powder. “It’s very, very hard, in general, to prove exactly what caus...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Environmental Health HealthSummit19 Research toxins Source Type: news
Conclusion: This is the first description of gC1qR expression in MPM. The data identify gC1qR as a potential new prognostic factor in patients treated with surgery and chemotherapy.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
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