[Genomics of neuroendocrine tumors of the lung and gastrointestinal tract: similarities and differences].

[Genomics of neuroendocrine tumors of the lung and gastrointestinal tract: similarities and differences]. Magy Onkol. 2018 Jul 20;62(2):77-82 Authors: Tímár J, Patócs A Abstract The incidence of neuroendocrine tumors sharply increased in the past years. It is also important that beside the relatively benign, slow growing tumors, prevalence of aggressive neuroendocrine carcinomas is also increasing. It is now evident that the carcinoids are genetically heterogeneous entities, localized to lung, pancreas or to the small intestines. A significant proportion of these neuroendocrine tumors are associated with hereditary syndromes but the etiology of the sporadic versions is still unknown, although in case of the lung, neuroendocrine carcinomas have a similar etiology than the non-endocrine carcinomas. This review summarizes the results of recent complex genomic analyses. Based on these data it is evident that the neuroendocrine tumors of the lung are different as compared to gastrointestinal ones. These genetic differences may fundamentally affect their biology, prognosis and therapy which must be considered. PMID: 30027934 [PubMed - in process]
Source: Magyar Onkologia - Category: Cancer & Oncology Authors: Tags: Magy Onkol Source Type: research