Isoliquiritigenin exerts antioxidant activity in Caenorhabditis elegans via insulin-like signaling pathway and SKN-1

Conclusion: The present study identified isoliquiritigenin as the most active antioxidant compound in G. uralensis. It exerts its effect by activating the transcription factors DAF-16/FOXO and SKN-1/Nrf2 which regulate many genes, including those which code for proteins of antioxidative response. This implicates isoliquiritigenin as a possible supplement drug against oxidative stress especially in neurodegenerative diseases.Graphical Abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research