The effect of metformin versus placebo in combination with insulin analogues on bone mineral density and trabecular bone score in patients with type 2 diabetes mellitus: a randomized placebo-controlled trial

ConclusionsEighteen months of treatment with metformin had no significant effect on BMD in the spine and hip or TBS in patients with T2DM compared with a placebo. TBS decreased significantly in both groups.Trial registrationClinicalTrials.gov (NCT00657943)
Source: Osteoporosis International - Category: Orthopaedics Source Type: research