Zyxin promotes colon cancer tumorigenesis in a mitotic phosphorylation-dependent manner and through CDK8-mediated YAP activation [Cell Biology]

Zyxin is a member of the focal adhesion complex and plays a critical role in actin filament polymerization and cell motility. Several recent studies showed that Zyxin is a positive regulator of Yki/YAP (Yes-associated protein) signaling. However, little is known about the mechanisms by which Zyxin itself is regulated and...

Source: Proceedings of the National Academy of Sciences - July 17, 2018 Category: Science Authors: Jiuli Zhou, Yongji Zeng, Lian Cui, Xingcheng Chen, Seth Stauffer, Zhan Wang, Fang Yu, Subodh M. Lele, Geoffrey A. Talmon, Adrian R. Black, Yuanhong Chen, Jixin Dong Tags: PNAS Plus Source Type: research