Mechanism of Race-Dependent Platelet Activation Through the Protease-Activated Receptor-4 and Gq Signaling Axis.
CONCLUSIONS: Our study is the first to demonstrate that the Gq pathway is differentially regulated by race after PAR4 stimulation in human platelets. Furthermore, the racial difference in PAR4-mediated platelet aggregation persisted in the presence of cyclooxygenase and P2Y12 dual inhibition, suggesting that current antiplatelet therapy may provide less protection to blacks than whites.
PMID: 25278289 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tourdot BE, Conaway S, Niisuke K, Edelstein LC, Bray PF, Holinstat M Tags: Arterioscler Thromb Vasc Biol Source Type: research
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